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草药综合综述:重点关注当前疗法及植物成分在癌症治疗中的作用

Comprehensive Review on Herbal Medicine: Emphasis on Current Therapy and Role of Phytoconstituents for Cancer Treatment.

作者信息

Sharma Alok Nath, Dewangan Hitesh Kumar, Upadhyay Prabhat Kumar

机构信息

Institute of Pharmaceutical Research(IPR), GLA University, NH-2 Mathura Delhi Road, P.O.-Chaumuhan, Mathura, 281406 (U.P.), India.

Faculty of Pharmacy, Raja Balwant Singh Engineering Technical Campus, Bichpuri, Agra, 283102.

出版信息

Chem Biodivers. 2024 Mar;21(3):e202301468. doi: 10.1002/cbdv.202301468. Epub 2024 Feb 22.

Abstract

INTRODUCTION

Cancer poses a significant public health challenge in both developed and developing nations, with a rising global incidence of patients facing the threat of death due to abnormal cell proliferation.

AIM

Review explores the utilization of different parts of herbal medicinal plants and their active pharmaceutical constituents in the prevention and treatment of various types of cancer.

METHODOLOGY

Various anticancer medicinal plants have been identified, demonstrating their therapeutic effects by inhibiting cancer-stimulating enzymes and hormones, activating DNA repair processes, boosting the synthesis of protective stimulants, reducing the formation of free radicals, and enhancing individual immunity. Data for this study were gathered from diverse online bibliographic and databases, including Google, Google Scholar, Mendeley, Springer Link, Research Gate, and PubMed.

RESULT

Herbal drugs have a huge contribution to the inhibition of the progression of cancer.A large volume of clinical studies has reported the beneficial effects of herbal medicines on the survival, immune modulation, and quality of life (QOL) of cancer patients, when these herbal medicines are used in combination with conventional therapeutics.

CONCLUSION

The latest medicines for the clinical purpose (Above 50 %) are derived from herbal products. Furthermore, combination of these herbs with nanotechnology shows promise in treating specific carcinomas.

摘要

引言

癌症在发达国家和发展中国家都构成了重大的公共卫生挑战,全球因异常细胞增殖面临死亡威胁的患者发病率不断上升。

目的

综述探讨了草药药用植物不同部位及其活性药物成分在预防和治疗各类癌症中的应用。

方法

已鉴定出多种抗癌药用植物,它们通过抑制癌症刺激酶和激素、激活DNA修复过程、促进保护性刺激物的合成、减少自由基的形成以及增强个体免疫力来发挥治疗作用。本研究的数据来自各种在线书目和数据库,包括谷歌、谷歌学术、Mendeley、Springer Link、Research Gate和PubMed。

结果

草药药物对抑制癌症进展有巨大贡献。大量临床研究报告称,当这些草药与传统疗法联合使用时,对癌症患者的生存、免疫调节和生活质量(QOL)有有益影响。

结论

用于临床目的的最新药物(超过50%)源自草药产品。此外,这些草药与纳米技术的结合在治疗特定癌症方面显示出前景。

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