通过相分离对纳米级脂质体表面的TRAIL聚集体进行调控。
Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation.
作者信息
Zhang Zhenjiang, King Michael R
机构信息
Department of Biomedical Engineering, Vanderbilt University 2414 Highland Ave Nashville TN 37212 USA
出版信息
Nanoscale Adv. 2023 Dec 29;6(2):402-405. doi: 10.1039/d3na00841j. eCollection 2024 Jan 16.
Abstract
Phase-separated liposomes were used to formulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a protein that selectively kills cancer cells while sparing most healthy ones. By controlling the average number of TRAIL molecules per liposome, we demonstrate the ability to tune the formation of TRAIL clusters and their resulting apoptotic activity.
摘要
相分离脂质体被用于配制肿瘤坏死因子相关凋亡诱导配体（TRAIL），这是一种能选择性杀死癌细胞而使大多数健康细胞免受影响的蛋白质。通过控制每个脂质体上TRAIL分子的平均数量，我们展示了调节TRAIL簇形成及其凋亡活性的能力。
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