可溶性细胞因子 sCD163、sCD28、sCD80 和 sCTLA-4 作为检测免疫衰老的可溶性标志物候选物。
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence.
作者信息
Aprilia Andrea, Handono Kusworini, Sujuti Hidayat, Sabarudin Akhmad, Winaris Nuning
机构信息
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Clinical Pathology Department, Faculty of Medicine, Universitas Brawijaya, Veteran Street, Malang, East Java, 65145, Indonesia.
出版信息
Immun Ageing. 2024 Jan 20;21(1):9. doi: 10.1186/s12979-023-00405-0.
BACKGROUND
Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, especially those suffering from chronic inflammatory conditions such as autoimmune disease, malignancy, or chronic infection. This condition led to altered immune function and as consequent immune function is reduced. Detection of immunosenescence has been done by examining the immune risk profile (IRP), which uses flow cytometry. These tests are not always available in health facilities, especially in developing countries and require fresh whole blood samples. Therefore, it is necessary to find biomarkers that can be tested using stored serum to make it easier to refer to the examination. Here we proposed an insight for soluble biomarkers which represented immune cells activities and exhaustion, namely sCD163, sCD28, sCD80, and sCTLA-4. Those markers were reported to be elevated in chronic diseases that caused early aging and easily detected from serum samples using ELISA method, unlike IRP. Therefore, we conclude these soluble markers are beneficial to predict pathological condition of immunosenescence.
AIM
To identify soluble biomarkers that could replace IRP for detecting immunosenescence.
CONCLUSION
Soluble costimulatory molecule suchsCD163, sCD28, sCD80, and sCTLA-4 are potential biomarkers for detecting immunosenescence.
背景
炎症衰老，即免疫衰老的特征，表现为持续的慢性炎症且无法消退。它不仅影响老年人，也可能发生在年轻人身上，尤其是那些患有慢性炎症性疾病的人，如自身免疫性疾病、恶性肿瘤或慢性感染。这种情况导致免疫功能改变，进而免疫功能下降。免疫衰老的检测是通过检查免疫风险谱（IRP）来进行的，这需要使用流式细胞术。这些检测在医疗机构中并不总是可用，特别是在发展中国家，并且需要新鲜的全血样本。因此，有必要找到可以使用储存血清进行检测的生物标志物，以便更便于进行检查。在这里，我们提出了一种关于可溶性生物标志物的见解，这些标志物代表免疫细胞的活性和耗竭，即可溶性CD163（sCD163）、可溶性CD28（sCD28）、可溶性CD80（sCD80）和可溶性细胞毒性T淋巴细胞相关抗原4（sCTLA - 4）。据报道，与免疫风险谱不同，这些标志物在导致早衰的慢性疾病中升高，并且可以使用酶联免疫吸附测定（ELISA）方法从血清样本中轻松检测到。因此，我们得出结论，这些可溶性标志物有助于预测免疫衰老的病理状况。
目的
识别可替代免疫风险谱用于检测免疫衰老的可溶性生物标志物。
结论
可溶性共刺激分子如sCD163、sCD28、sCD80和sCTLA - 4是检测免疫衰老的潜在生物标志物。
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