Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, UK.
National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Obesity (Silver Spring). 2024 Mar;32(3):454-465. doi: 10.1002/oby.23976. Epub 2024 Jan 21.
The objective of this study was to investigate whether pausing a weight loss program for a defined period of time could enhance weight loss and reduce attrition.
Five databases and two trial registries were searched from inception to July 2023. Randomized-controlled trials of adults with overweight and/or obesity were included if they compared planned-pause interventions with continuous energy restriction (CER), usual care, or a minimal intervention. To be included, the weight loss intervention must have incorporated a pause of at least 1 week. Pooled mean differences for weight change and risk ratios for attrition were calculated using random-effects meta-analyses.
Nine intervention arms (N = 796 participants, 77% female) were included. Pooled results did not detect a significant difference in weight change between planned pauses and CER interventions at the end of the active intervention at a median 26 weeks (planned pauses vs. CER mean: -7.09 vs. -7.0 kg; mean difference: -0.09 kg; 95% CI: -1.10 to 0.93) or at final follow-up at a median 52 weeks (planned pauses vs. CER mean: -6.91 vs. -6.19 kg; mean difference: -0.72 kg; 95% CI: -2.92 to 1.48). There was no difference in attrition between planned pauses and CER interventions at the end of the active intervention (risk ratio: 1.20, 95% CI: 0.82 to 1.75) or at final follow-up (risk ratio: 1.04, 95% CI: 0.89 to 1.22).
Planned pauses were consistently found to be no more or less effective than CER for weight loss or attrition.
本研究旨在探讨暂停减肥计划是否能增强减肥效果并减少脱落率。
从建库到 2023 年 7 月,检索了 5 个数据库和 2 个试验注册处。纳入的研究对象为超重和/或肥胖的成年人,比较了计划暂停干预与持续能量限制(CER)、常规护理或最小干预的随机对照试验。纳入的减肥干预措施必须至少包含 1 周的暂停期。使用随机效应荟萃分析计算体重变化的平均差值和脱落风险比。
共纳入 9 个干预组(N=796 名参与者,77%为女性)。在积极干预结束时,即中位数为 26 周时,计划暂停与 CER 干预之间的体重变化无显著差异(计划暂停与 CER 平均差值:-7.09 与-7.0kg;平均差值:-0.09kg;95%CI:-1.10 至 0.93),在中位数为 52 周的最终随访时也无显著差异(计划暂停与 CER 平均差值:-6.91 与-6.19kg;平均差值:-0.72kg;95%CI:-2.92 至 1.48)。在积极干预结束时(风险比:1.20,95%CI:0.82 至 1.75)或最终随访时(风险比:1.04,95%CI:0.89 至 1.22),计划暂停与 CER 干预之间的脱落率也无差异。
计划暂停在减肥或脱落方面与 CER 一样有效或无效。