卵巢癌、输卵管癌和原发性腹膜癌的发病、死亡和生存趋势：基于人群的 15 年分析。

Trends in ovarian, fallopian tube, and primary peritoneal cancer incidence, mortality, and survival: A 15-year population-based analysis.

机构信息

Stanford University School of Medicine, Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Palo Alto, CA, United States of America.

出版信息

Gynecol Oncol. 2024 May;184:190-197. doi: 10.1016/j.ygyno.2024.01.034. Epub 2024 Feb 7.

DOI:10.1016/j.ygyno.2024.01.034

PMID:38330833

Abstract

OBJECTIVE

To characterize trends in ovarian, fallopian tube, and primary peritoneal cancer incidence and incidence-based mortality based on histology and site of origin.

METHODS

We obtained age-adjusted incidence and incidence-based mortality for patients with ovarian, fallopian tube, and primary peritoneal cancer from 2000 to 2019 from the US SEER 17 database. Joinpoint 4.9.1.0 was used to characterize log-linear time trends.

RESULTS

The incidence and incidence-based mortality of all cancers trended down during the study period. The incidence of epithelial cancers decreased from 2004 to 2019 (AAPC -1.2%, p < 0.001), including that of high-grade (2006-2019: APC -1.2%, p < 0.05) and low-grade (2003-2019: APC -2.4%, p < 0.05) epithelial cancers. There was no change in incidence or incidence-based mortality for ovarian stromal and germ cell cancers.

CONCLUSION

There has been a decrease in the incidence and incidence-based mortality of ovarian, fallopian tube, and primary peritoneal cancer, primarily due to reductions in advanced stage epithelial cancers originating in the ovary, fallopian tube, or peritoneum.

摘要

目的

根据组织学和起源部位，描述卵巢、输卵管和原发性腹膜癌的发病率和基于发病率的死亡率的趋势。

方法

我们从美国 SEER 17 数据库获得了 2000 年至 2019 年期间卵巢、输卵管和原发性腹膜癌患者的年龄调整发病率和基于发病率的死亡率。使用 Joinpoint 4.9.1.0 来描述对数线性时间趋势。

结果

在研究期间，所有癌症的发病率和基于发病率的死亡率呈下降趋势。上皮性癌症的发病率从 2004 年下降到 2019 年（AAPC-1.2%，p<0.001），包括高级别（2006-2019 年：APC-1.2%，p<0.05）和低级别（2003-2019 年：APC-2.4%，p<0.05）上皮性癌症。卵巢间质和生殖细胞癌的发病率或基于发病率的死亡率没有变化。