活化蛋白 C 释放的内皮细胞外囊泡的细胞保护作用的潜在机制。
A potential mechanism for the cytoprotective effects of activated protein C-released endothelial extracellular vesicles.
机构信息
Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
出版信息
Blood. 2024 Apr 18;143(16):1670-1675. doi: 10.1182/blood.2023023518.
Abstract
Activated protein C (APC) was shown to release extracellular vesicles (EVs). APC bound to the EVs was thought to be responsible for cytoprotection. Our study demonstrates that the cytoprotective effects of APC-released EVs are independent of APC. APC-released EVs carry anti-inflammatory microRNAs in their cargo.
摘要
激活蛋白 C（APC）被证明可以释放细胞外囊泡（EVs）。人们认为与 EVs 结合的 APC 负责细胞保护。我们的研究表明，APC 释放的 EVs 的细胞保护作用与 APC 无关。APC 释放的 EVs 在其货物中携带抗炎 microRNAs。
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