分化不确定的中枢神经系统肿瘤
Central nervous system tumors of uncertain differentiation.
作者信息
A Jacobo Javier
机构信息
Neuro-Oncology Unit, Center for the Treatment and Investigation About Cancer (CTIC), Bogotá, Colombia.
出版信息
World Neurosurg X. 2024 Feb 24;22:100349. doi: 10.1016/j.wnsx.2024.100349. eCollection 2024 Apr.
BACKGROUND
The 2021 World Health Organization classification for brain tumors introduced several new entities and categories.Tumors of uncertain differentiation are a new subcategory that includes the intracranial mesenchymal tumor, FET-CREB fusion-positive; the CIC-rearranged sarcoma; and the Primary intracranial sarcoma, DICER1-mutant.
METHODS
A search was made in Pubmed and Google Scholar to include all articles with the term "uncertain differentiation", "Mesenchymal, non-meningothelial", "FET-CREB fusion positive", "DICER1-mutant sarcoma" and "CIC-Rearranged sarcoma" in their title. These articles were reviewed to draft a concise review on this subject.
RESULTS
This review on CNS non-meningothelial mesenchymal tumors is meant to provide an update with diagnostic, prognostic, and therapeutic implications.
CONCLUSION
Tumors of uncertain differentiation include a variety of mesenchymal, non-meningothelial tumors that have distinct molecular characteristics and consequently behave in a very particular matter.Given that these tumors have been described only recently, there is still an important lack of information regarding the most appropriate treatment and prognosis.
背景
2021年世界卫生组织脑肿瘤分类引入了几个新的实体和类别。分化不确定的肿瘤是一个新的亚类，包括颅内间充质肿瘤，FET-CREB融合阳性；CIC重排肉瘤；以及原发性颅内肉瘤，DICER1突变型。
方法
在PubMed和谷歌学术上进行搜索，纳入标题中包含“分化不确定”“间充质，非脑膜”“FET-CREB融合阳性”“DICER1突变型肉瘤”和“CIC重排肉瘤”等术语的所有文章。对这些文章进行综述，以撰写关于该主题的简明综述。
结果
本关于中枢神经系统非脑膜间充质肿瘤的综述旨在提供有关诊断、预后和治疗意义的最新信息。
结论
分化不确定的肿瘤包括多种具有独特分子特征且行为非常特殊的间充质、非脑膜肿瘤。鉴于这些肿瘤最近才被描述，关于最合适的治疗和预后仍存在重要的信息不足。
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