Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Genetics and Advanced Medical Technology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Reprod Sci. 2024 Jul;31(7):1781-1799. doi: 10.1007/s43032-024-01521-y. Epub 2024 Mar 26.
The study encompassing research papers documented in the last two decades pertaining to the possible influence of bisphenol A (BPA) on the fertility of females are appraised with emphasis on the influence of BPA in reproductive organs (uterus and ovaries) and pregnancy outcomes including discussion on the reproductive process (implantation, estrous cycle, hormone secretion); outcomes reveal a connection amongst BPA and female infertility. Ovary, uterus, and its shape as well as function can alter a person's ability to become pregnant by influencing the hypothalamus-pituitary axis in the ovarian model. Additionally, implantation and the estrous cycle may be affected by BPA. However, more research is warranted to comprehend the underlying action mechanisms and to promptly identify any imminent reproductive harm.
该研究综述了过去二十年中有关双酚 A(BPA)可能对女性生育能力影响的研究论文,重点评估了 BPA 对生殖器官(子宫和卵巢)和妊娠结局的影响,包括对生殖过程(着床、发情周期、激素分泌)的讨论;研究结果表明 BPA 与女性不孕之间存在关联。BPA 可改变卵巢模型中的下丘脑-垂体轴,从而影响卵巢、子宫及其形状和功能,进而改变一个人怀孕的能力。此外,BPA 还可能影响着床和发情周期。然而,需要进一步的研究来了解其潜在的作用机制,并及时发现任何潜在的生殖危害。