SOX17：早期 CRC 中免疫破坏的逃逸途径。

SOX17: escape route from immune destruction in early CRC.

机构信息

First University Department of Respiratory Medicine, 'Sotiria' Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

Trends Mol Med. 2024 Jul;30(7):609-611. doi: 10.1016/j.molmed.2024.04.001. Epub 2024 Apr 9.

DOI:10.1016/j.molmed.2024.04.001

PMID:38594095

Abstract

In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.

摘要

在最近发表在《自然》杂志上的一份报告中，Goto 等人揭示了早期结直肠癌（CRC）细胞采用的一种新的免疫逃逸机制，该机制基于性别决定区 Y（SRY）框转录因子 17（SOX17）。利用结直肠腺瘤和癌症模型进行全面的转录组/染色质分析，这项工作表明 SOX17 产生免疫沉默富含亮氨酸重复的 G 蛋白偶联受体 5（LGR5）肿瘤细胞，这些细胞抑制干扰素 γ（IFNγ）信号并促进免疫逃逸。