褪黑素的抗氧化作用：动物研究的系统评价
Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies.
作者信息
Monteiro Karla Krislane Alves Costa, Shiroma Marcos Eiji, Damous Luciana Lamarão, Simões Manuel de Jesus, Simões Ricardo Dos Santos, Cipolla-Neto José, Baracat Edmund Chada, Soares-Jr Jose Maria
机构信息
Laboratório de Ginecologia Estrutural e Molecular (LIM-58), Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas HC-FMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, Brazil.
Laboratório de Neurobiologia, Departamento de Fisiologia, Instituto de Ciências Médicas (ICB-I), Universidade de São Paulo, São Paulo 05508-000, Brazil.
出版信息
Antioxidants (Basel). 2024 Apr 7;13(4):439. doi: 10.3390/antiox13040439.
UNLABELLED
Melatonin is an indoleamine with crucial antioxidant properties that are used to combat inflammatory and neoplastic processes, as well as control transplants. However, the clinical applications of melatonin have not yet been fully consolidated in the literature and require in-depth analysis.
OBJECTIVES
This study reviewed the literature on the antioxidant properties of melatonin in rat models.
METHODS
We followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses and used the PubMed, LILACS, and Cochrane databases, Google Scholar, and article references, irrespective of publication time.
RESULTS
Ten articles involving 485 rats were selected, and the effects of melatonin on antioxidant markers were investigated. Melatonin increased superoxide dismutase in nine studies, glutathione peroxidase in seven studies, and catalase in five studies. In contrast, melatonin reduced glutathione in three studies and malonaldehyde in seven of eight studies.
CONCLUSION
Our findings suggest that melatonin effectively reduces oxidative stress.
未标注
褪黑素是一种具有关键抗氧化特性的吲哚胺，可用于对抗炎症和肿瘤过程以及控制移植。然而，褪黑素的临床应用在文献中尚未完全巩固，需要深入分析。
目的
本研究回顾了关于褪黑素在大鼠模型中抗氧化特性的文献。
方法
我们遵循系统评价和Meta分析的首选报告项目指南，使用了PubMed、LILACS和Cochrane数据库、谷歌学术以及文章参考文献，不考虑发表时间。
结果
选择了10篇涉及485只大鼠的文章，并研究了褪黑素对抗氧化标志物的影响。在9项研究中，褪黑素增加了超氧化物歧化酶，在7项研究中增加了谷胱甘肽过氧化物酶，在5项研究中增加了过氧化氢酶。相比之下，在3项研究中褪黑素降低了谷胱甘肽，在8项研究中的7项中降低了丙二醛。
结论
我们的研究结果表明，褪黑素能有效降低氧化应激。
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