牙髓干细胞在脊髓损伤中的潜在治疗作用。
The potential therapeutic roles of dental pulp stem cells in spinal cord injury.
作者信息
Fu Jing, Li Wenjie, Mao Tengfei, Chen Zaipeng, Lai Lili, Lin Jiachen, Nie Zhiqiang, Sun Yunkai, Chen Yanqin, Zhang Qin, Li Xigong
机构信息
Department of Stomatology, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Department of Anesthesiology and Surgery, Qingdao Municipal Hospital Group, Qingdao, China.
出版信息
Front Mol Biosci. 2024 Apr 29;11:1363838. doi: 10.3389/fmolb.2024.1363838. eCollection 2024.
Spinal cord injury (SCI) can lead to serious functional disorders, which have serious impacts on patients and society. The current traditional treatments of SCI are not effective the injured spinal cord is difficult to repair and regenerate. In recent years, stem cell transplantation for the treatment of SCI has been a hot research topic. Dental pulp stem cells have strong abilities of self-renewal and multi-directional differentiation, and have been applied for tissue engineering and regenerative medicine. And dental pulp stem cells have certain advantages in neuro-regenetation, bringing new hope to biotherapy for SCI. This article reviews the characteristics of dental pulp stem cells and their research progress in the treatment of SCI.
脊髓损伤（SCI）可导致严重的功能障碍，这对患者和社会都有严重影响。目前SCI的传统治疗方法效果不佳，受损脊髓难以修复和再生。近年来，干细胞移植治疗SCI一直是研究热点。牙髓干细胞具有强大的自我更新和多向分化能力，已应用于组织工程和再生医学。并且牙髓干细胞在神经再生方面具有一定优势，为SCI的生物治疗带来了新希望。本文综述了牙髓干细胞的特性及其在SCI治疗中的研究进展。
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