验证结构断开假说：髓磷脂含量与健康衰老过程中的记忆相关。
Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging.
作者信息
Mendez Colmenares Andrea, Thomas Michael L, Anderson Charles, Arciniegas David B, Calhoun Vince, Choi In-Young, Kramer Arthur F, Li Kaigang, Lee Jongho, Lee Phil, Burzynska Agnieszka Z
机构信息
The BRAiN lab, Department of Human Development and Family Studies/Molecular, Cellular and Integrative Neurosciences, Colorado State University, Behavioral Sciences Building, 303, 410 W Pitkin St, Fort Collins, CO 80523, USA.
Department of Psychology, Colorado State University, Behavioral Sciences Building, 303, 410 W Pitkin, St, Fort Collins, CO 80523, USA.
出版信息
Neurobiol Aging. 2024 Sep;141:21-33. doi: 10.1016/j.neurobiolaging.2024.05.013. Epub 2024 May 23.
INTRODUCTION
The "structural disconnection" hypothesis of cognitive aging suggests that deterioration of white matter (WM), especially myelin, results in cognitive decline, yet in vivo evidence is inconclusive.
METHODS
We examined age differences in WM microstructure using Myelin Water Imaging and Diffusion Tensor Imaging in 141 healthy participants (age 20-79). We used the Virginia Cognitive Aging Project and the NIH Toolbox® to generate composites for memory, processing speed, and executive function.
RESULTS
Voxel-wise analyses showed that lower myelin water fraction (MWF), predominantly in prefrontal WM, genu of the corpus callosum, and posterior limb of the internal capsule was associated with reduced memory performance after controlling for age, sex, and education. In structural equation modeling, MWF in the prefrontal white matter and genu of the corpus callosum significantly mediated the effect of age on memory, whereas fractional anisotropy (FA) did not.
DISCUSSION
Our findings support the disconnection hypothesis, showing that myelin decline contributes to age-related memory loss and opens avenues for interventions targeting myelin health.
引言
认知衰老的“结构脱节”假说认为，白质（WM）尤其是髓磷脂的退化会导致认知能力下降，但体内证据尚无定论。
方法
我们使用髓磷脂水成像和扩散张量成像技术，对141名健康参与者（年龄20 - 79岁）的WM微观结构进行了年龄差异研究。我们使用弗吉尼亚认知衰老项目和美国国立卫生研究院工具箱生成记忆、处理速度和执行功能的综合指标。
结果
体素分析显示，在控制年龄、性别和教育程度后，较低的髓磷脂水分数（MWF）主要出现在前额叶白质、胼胝体膝部和内囊后肢，与记忆表现下降有关。在结构方程模型中，前额叶白质和胼胝体膝部的MWF显著介导了年龄对记忆的影响，而分数各向异性（FA）则没有。
讨论
我们的研究结果支持脱节假说，表明髓磷脂减少导致与年龄相关的记忆丧失，并为针对髓磷脂健康的干预措施开辟了道路。
Zotero 插件