定量蛋白质组学在转化药理学和精准医学中的应用：现状与未来展望。

Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook.

机构信息

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.); Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (Z.M.A.-M., A.R.-H.); Department of Plant Physiology, Umeå University, Umeå, Sweden (C.W.); Certara UK, Sheffield, United Kingdom (A.R.-H.); and Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, the University of Rhode Island, Kingston, Rhode Island (B.A.)

出版信息

Drug Metab Dispos. 2024 Oct 16;52(11):1208-1216. doi: 10.1124/dmd.124.001600.

DOI:10.1124/dmd.124.001600

PMID:38821856

Abstract

Over the past 20 years, quantitative proteomics has contributed a wealth of protein expression data, which are currently used for a variety of systems pharmacology applications, as a complement or a surrogate for activity of the corresponding proteins. A symposium at the 25th North American International Society for the Study of Xenobiotics meeting, in Boston, in September 2023, was held to explore current and emerging applications of quantitative proteomics in translational pharmacology and strategies for improved integration into model-informed drug development based on practical experience of each of the presenters. A summary of the talks and discussions is presented in this perspective alongside future outlook that was outlined for future meetings. SIGNIFICANCE STATEMENT: This perspective explores current and emerging applications of quantitative proteomics in translational pharmacology and precision medicine and outlines the outlook for improved integration into model-informed drug development.

摘要

在过去的 20 年里，定量蛋白质组学已经提供了大量的蛋白质表达数据，这些数据目前被用于各种系统药理学应用，作为相应蛋白质活性的补充或替代。2023 年 9 月，在波士顿举行的第 25 届北美国际异生素研究学会会议上举行了一次研讨会，旨在探讨定量蛋白质组学在转化药理学中的当前和新兴应用，以及根据每位演讲者的实际经验，将其更好地纳入基于模型的药物开发的策略。本文通过对演讲内容和讨论的总结，以及对未来会议的展望，阐述了定量蛋白质组学在转化药理学和精准医学中的应用和展望。