Suppr超能文献

发展中国家的新生儿筛查:当务之急

Newborn Screening in Developing Countries: The Need of the Hour.

作者信息

Gaikwad Sarika, Ganvir Shubhangi, Uke Punam

机构信息

Department of Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

Department of Pediatrics, Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals, Mumbai, IND.

出版信息

Cureus. 2024 May 3;16(5):e59572. doi: 10.7759/cureus.59572. eCollection 2024 May.

Abstract

Screening newborns is recognized as an important health policy. It is cost-effective and is implemented as a national health program in most developed countries. Though births in developing countries contribute to more than half of the total births globally, newborn screening (NBS) is not yet implemented in most developing countries. If not diagnosed and treated timely, some of these infants will contribute to neonatal mortality. In contrast, others will have long-term sequelae like developmental delay, learning disabilities, behavioral abnormalities, and backward academic performance in the future. In addition, the diagnosis, management, and treatment of these conditions also carry a significant financial as well as emotional burden on the family. An NBS program can be the most rational and effective way to prevent such morbidities and mortalities. NBS in developing countries competes with other health issues such as the control of infectious diseases, vaccinations, and poor nutrition. Also, lack of government support, poor economy, inadequate public health education, lack of awareness among health care workers, early discharge from hospital, and many births out of hospital are the significant obstacles in the countries that lack total coverage. It is high time now to change our attitude; our focus should be not only on the reduction of mortality and infectious morbidity but also on reducing disabilities with the introduction of screening for newborns. Integrating NBS with the national healthcare system is crucial for successful implementation in developing countries. Integration should also include a payment scheme to reduce the economic burden on families. In recent years, many developing countries have started implementing pilot projects as a step toward the national program of screening newborns.

摘要

筛查新生儿被视为一项重要的卫生政策。它具有成本效益,在大多数发达国家作为一项国家卫生计划实施。尽管发展中国家的出生人口占全球出生人口总数的一半以上,但大多数发展中国家尚未实施新生儿筛查(NBS)。如果不及早诊断和治疗,其中一些婴儿将导致新生儿死亡。相比之下,其他婴儿未来将出现长期后遗症,如发育迟缓、学习障碍、行为异常和学业成绩落后。此外,对这些疾病的诊断、管理和治疗也给家庭带来了巨大的经济和情感负担。新生儿筛查计划可能是预防此类发病和死亡的最合理、最有效的方法。发展中国家的新生儿筛查与其他卫生问题竞争,如传染病控制、疫苗接种和营养不良。此外,缺乏政府支持、经济状况不佳、公共卫生教育不足、医护人员意识淡薄、过早出院以及许多在家分娩等,都是在那些缺乏全面覆盖的国家中的重大障碍。现在是时候改变我们的态度了;我们的重点不仅应放在降低死亡率和传染病发病率上,还应通过引入新生儿筛查来减少残疾。将新生儿筛查纳入国家医疗保健系统对于在发展中国家成功实施至关重要。整合还应包括一项支付计划,以减轻家庭的经济负担。近年来,许多发展中国家已开始实施试点项目,作为迈向国家新生儿筛查计划的一步。

相似文献

1
Newborn Screening in Developing Countries: The Need of the Hour.
Cureus. 2024 May 3;16(5):e59572. doi: 10.7759/cureus.59572. eCollection 2024 May.
3
Newborn screening for lysosomal diseases: current status and potential interface with population medical genetics in Latin America.
J Inherit Metab Dis. 2012 Sep;35(5):871-7. doi: 10.1007/s10545-011-9436-z. Epub 2012 Jan 10.
4
The future of Cochrane Neonatal.
Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12.
5
Human and Economic Cost of Disease Burden Due to Congenital Hypothyroidism in India: Too Little, but Not Too Late.
Front Pediatr. 2022 May 3;10:788589. doi: 10.3389/fped.2022.788589. eCollection 2022.
6
Sepsis Care Pathway 2019.
Qatar Med J. 2019 Nov 7;2019(2):4. doi: 10.5339/qmj.2019.qccc.4. eCollection 2019.
8
Newborn screening in the developing countries.
Curr Opin Pediatr. 2018 Dec;30(6):734-739. doi: 10.1097/MOP.0000000000000683.
9
The Minderoo-Monaco Commission on Plastics and Human Health.
Ann Glob Health. 2023 Mar 21;89(1):23. doi: 10.5334/aogh.4056. eCollection 2023.

引用本文的文献

1
Global clubfoot treatment in 2023: an overview of advances and outcomes.
BMJ Glob Health. 2025 Mar 28;10(3):e017861. doi: 10.1136/bmjgh-2024-017861.
2
Diagnosing cystic fibrosis in low- and middle-income countries: challenges and strategies.
Orphanet J Rare Dis. 2024 Dec 20;19(1):482. doi: 10.1186/s13023-024-03506-1.
3
Genomic Newborn Screening for Pediatric Cancer Predisposition Syndromes: A Holistic Approach.
Cancers (Basel). 2024 May 26;16(11):2017. doi: 10.3390/cancers16112017.

本文引用的文献

1
The Importance of Neonatal Screening for Galactosemia.
Nutrients. 2022 Dec 20;15(1):10. doi: 10.3390/nu15010010.
2
Newborn screening for genetic disorders: Current status and prospects for the future.
Pediatr Investig. 2022 Oct 24;6(4):291-298. doi: 10.1002/ped4.12343. eCollection 2022 Dec.
4
Universal Implementation of Newborn Screening in India.
Int J Neonatal Screen. 2020 Mar 25;6(2):24. doi: 10.3390/ijns6020024. eCollection 2020 Jun.
5
The Genetic Landscape and Epidemiology of Phenylketonuria.
Am J Hum Genet. 2020 Aug 6;107(2):234-250. doi: 10.1016/j.ajhg.2020.06.006. Epub 2020 Jul 14.
6
The Kuwait National Primary Immunodeficiency Registry 2004-2018.
Front Immunol. 2019 Jul 24;10:1754. doi: 10.3389/fimmu.2019.01754. eCollection 2019.
9
Newborn Screening for Congenital Hypothyroidism and Congenital Adrenal Hyperplasia.
Indian J Pediatr. 2018 Nov;85(11):935-940. doi: 10.1007/s12098-018-2645-9. Epub 2018 Mar 17.
10
Current and future perspective of newborn screening: an Indian scenario.
J Pediatr Endocrinol Metab. 2016 Jan;29(1):5-13. doi: 10.1515/jpem-2015-0009.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验