中性粒细胞/淋巴细胞和血小板/淋巴细胞比值与墨西哥慢性血液透析患者炎症和生存的关系。

Association of neutrophil/lymphocyte and platelet/lymphocyte ratios with inflammation and survival in Mexican patients on chronic hemodialysis.

机构信息

Department of Nephrology, Hospital General Regional No.1, Instituto Mexicano del Seguro Social, Morelia, Mexico.

Facultad de Ciencias Médicas y Biológicas "Dr. Ignacio Chávez", Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico.

出版信息

Ther Apher Dial. 2024 Dec;28(6):880-885. doi: 10.1111/1744-9987.14175. Epub 2024 Jun 7.

DOI:10.1111/1744-9987.14175

PMID:38845452

Abstract

INTRODUCTION

Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are markers of systemic inflammatory status. The relationship between NLR, PLR, and mortality is controversial among hemodialysis (HD) patients.

OBJECTIVE

Evaluate NLR and PLR in the prediction of mortality in chronic HD patients.

MATERIALS AND METHODS

We analyzed 130 patients with a follow-up for 66 months. Four groups were established according to NLR-PLR values. Kaplan-Meier curves and Cox proportional hazards analysis were used.

RESULTS

NLR-PLR correlated positively with C-reactive protein. Cox regression analysis for overall mortality among the four groups included age (HR 1.027, 95% CI 1.003-1.053) and albumin (HR 0.25, 95% CI 0.073-0.85). For cardiovascular (CV) mortality only pulse pressure differential (PPD) was included (HR 1.033; 95% CI 1.014-1.052). Low NLRs and high PLRs were associated with CV mortality (Log Rank test, p = 0.033).

CONCLUSIONS

Low NLRs and high PLRs predict the risk of CV mortality among HD patients.

摘要

简介

中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）是全身炎症状态的标志物。在血液透析（HD）患者中，NLR 和 PLR 与死亡率之间的关系存在争议。

目的

评估 NLR 和 PLR 在预测慢性 HD 患者死亡率中的作用。

材料和方法

我们分析了 130 例患者，随访时间为 66 个月。根据 NLR-PLR 值将患者分为四组。采用 Kaplan-Meier 曲线和 Cox 比例风险分析。

结果

NLR-PLR 与 C 反应蛋白呈正相关。对四组患者全因死亡率的 Cox 回归分析包括年龄（HR 1.027，95%CI 1.003-1.053）和白蛋白（HR 0.25，95%CI 0.073-0.85）。对于心血管（CV）死亡率，仅包括脉压差（PPD）（HR 1.033；95%CI 1.014-1.052）。低 NLR 和高 PLR 与 CV 死亡率相关（Log Rank 检验，p=0.033）。