硼介导的一锅法制备水杨醛——苯甲醛的C-H羟基化反应
Boron-mediated one-pot access to salicylaldehydes -C-H hydroxylation of benzaldehydes.
作者信息
Wang Ruiyang, Feng Xu, Feng Boya, Chen Yu
机构信息
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen) Nanjing 210014 China
出版信息
RSC Adv. 2024 Jun 20;14(28):19922-19925. doi: 10.1039/d4ra02994a. eCollection 2024 Jun 18.
A novel protocol has been devised for the -C-H hydroxylation of benzaldehydes. Directed by a transient imine group, the borylation of benzaldehydes, sequentially followed by the hydroxylation, furnishes diverse salicylaldehydes in a one-pot manner. The resultant salicylaldehydes could be readily applied in the downstream synthesis to produce bioactive molecules.
已设计出一种用于苯甲醛-C-H羟基化的新方案。在瞬态亚胺基团的导向下，苯甲醛先进行硼氢化反应，随后进行羟基化反应，以一锅法提供多种水杨醛。所得的水杨醛可很容易地应用于下游合成以生产生物活性分子。
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