聚焦慢性淋巴细胞白血病中的边缘区IGHV突变状态。
Spotlight on borderline-IGHV mutational status in chronic lymphocytic leukemia.
作者信息
Rammal Souraya, Semaan Warde, Aprahamian Natalia, Moussallem Romy, Chebly Alain
机构信息
Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
出版信息
Front Oncol. 2024 Jun 6;14:1430225. doi: 10.3389/fonc.2024.1430225. eCollection 2024.
Mutated or unmutated immunoglobulin heavy chain ( gene is an important prognostic factor in chronic lymphocytic leukemia (CLL). However, a small fraction of patients with CLL are classified as borderline (BL)-IGHV. Few data are available on this subgroup of CLL. In this paper, we retrospectively report and analyze data from 21 patients with BL-IGHV CLL, showing the heterogeneity of this subgroup of CLL and paving the way for more research focusing on this entity to optimize the management and treatment of patients with Borderline-IGHV CLL.
突变或未突变的免疫球蛋白重链（基因）是慢性淋巴细胞白血病（CLL）的一个重要预后因素。然而，一小部分CLL患者被归类为临界（BL）-IGHV。关于这一CLL亚组的数据很少。在本文中，我们回顾性报告并分析了21例BL-IGHV CLL患者的数据，显示了这一CLL亚组的异质性，并为更多聚焦于该实体的研究铺平道路，以优化临界-IGHV CLL患者的管理和治疗。
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