The Puerto Rico Young Adults' Stress, Contextual, Behavioral, and Cardiometabolic Risk (PR-OUTLOOK) Study: design and methods.

The Puerto Rico (PR) Young Adults' Stress, Contextual, Behavioral and Cardiometabolic Risk Study (PR-OUTLOOK) is investigating overall and component-specific cardiovascular health (CVH) and cardiovascular disease (CVD) risk factors in a sample of young Puerto Rican adults (aged 18-29 years) in PR (target n = 3000) and examining relationships between individual-, family- or social-, and neighborhood-level stress and resilience factors and CVH and CVD risk factors. The study researchers are conducting standardized measurements of CVH and CVD risk factors and demographic, behavioral, psychosocial, neighborhood, and contextual variables and establishing a biorepository of blood, saliva, urine, stool, and hair samples. The assessment methods are aligned with other National Heart, Lung, and Blood Institute-funded studies: the Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends of adults aged 30-75 years; the Hispanic Community Health Study/Study of Latinos; the Boston Puerto Rican Health Study; and the Coronary Artery Risk Development in Young Adults. PR-OUTLOOK data and the study biorepository will facilitate future longitudinal studies of the temporality of associations between stress and resilient factors and CVH and CVD risk factors among young Puerto Ricans. These resources have potential for advancing the scientific understanding of these conditions in a high-risk but understudied young population.