活性氧在胃癌中的作用。
The role of reactive oxygen species in gastric cancer.
机构信息
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Department of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
出版信息
Cancer Biol Med. 2024 Jul 9;21(9):740-53. doi: 10.20892/j.issn.2095-3941.2024.0182.
Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.
胃癌（GC）在全球的癌症发病率中排名第五，在癌症相关死亡率中排名第四。活性氧（ROS）是高度氧化的氧衍生产物，在细胞信号调节和维持内部平衡中起着关键作用。ROS 与 GC 的发生、发展和治疗密切相关。本综述总结了 ROS 的来源及其对 GC 的双向调节作用的最新研究结果，并讨论了与 ROS 诱导相关的各种 GC 治疗方法。此外，还总结了具有最高开发潜力和在抗 GC 研究中应用潜力的天然小分子化合物对 ROS 的调节作用。本综述的目的是加速调节 ROS 水平作为 GC 治疗策略的临床应用。
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