Semaphorin 4A Maintains Trophoblastic Function via Activating the STAT3 Pathway.

The migration, proliferation, and apoptosis of trophoblastic cells play a crucial role in ensuring the effective preservation of pregnancy at the maternal-fetal interface. Any deviations in the structure and function of these cells might potentially result in the development of numerous pregnancy-related disorders, including missed abortion (MA). This study involved the examination of () expression in missed abortion = 18) and normal early pregnancy ( = 18) villus. The findings of this study indicate a statistically significant decrease in the expression of SEMA4A in the villi of individuals diagnosed with missed abortion, as compared to the control group. The results of our vitro study showed that promoted the migration and proliferation of trophoblast cells and inhibited their apoptosis. Subsequent studies have shown that may be involved in regulating , , , and levels. In summary, the findings of this study indicate a correlation between the decreased level of in chorionic villi and missed abortion. These results offer novel theoretical insights into the proper implantation and development of embryos at the maternal-fetal interface.