探索 Sirtuins：管理射血分数保留型心力衰竭的新前沿。
Exploring Sirtuins: New Frontiers in Managing Heart Failure with Preserved Ejection Fraction.
机构信息
Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China.
Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730031, China.
出版信息
Int J Mol Sci. 2024 Jul 15;25(14):7740. doi: 10.3390/ijms25147740.
With increasing research, the sirtuin (SIRT) protein family has become increasingly understood. Studies have demonstrated that SIRTs can aid in metabolism and affect various physiological processes, such as atherosclerosis, heart failure (HF), hypertension, type 2 diabetes, and other related disorders. Although the pathogenesis of HF with preserved ejection fraction (HFpEF) has not yet been clarified, SIRTs have a role in its development. Therefore, SIRTs may offer a fresh approach to the diagnosis, treatment, and prevention of HFpEF as a novel therapeutic intervention target.
随着研究的不断深入，Sirtuin（SIRT）蛋白家族的功能逐渐被阐明。研究表明，SIRTs 可以辅助代谢，并影响多种生理过程，如动脉粥样硬化、心力衰竭（HF）、高血压、2 型糖尿病和其他相关疾病。尽管射血分数保留的心力衰竭（HFpEF）的发病机制尚未阐明，但 SIRTs 在其发生发展中发挥作用。因此，SIRTs 可能为 HFpEF 的诊断、治疗和预防提供新的思路，成为一种新的治疗干预靶点。
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