Stereoconvergent and Enantioselective Synthesis of -Homoallylic Alcohols via Nickel-Catalyzed Reductive Coupling of /-1,3-Dienes with Aldehydes.

Stereoconvergent reactions enable the transformation of mixed stereoisomers into well-defined, chiral products─a crucial strategy for handling /-mixed olefins, which are common but challenging substrates in organic synthesis. Herein, we report a stereoconvergent and highly enantioselective method for synthesizing -homoallylic alcohols via the nickel-catalyzed reductive coupling of /-mixed 1,3-dienes with aldehydes. This process is enabled by an -heterocyclic carbene ligand characterized by -symmetric backbone chirality and bulky 2,6-diisopropyl -aryl substituents. Our method achieves excellent stereocontrol over both enantioselectivity and -selectivity in a single step, producing chiral -homoallylic alcohols that are valuable in natural products and pharmaceuticals.