2020 - 2023年华东地区猪流行性腹泻病毒的系统发育和遗传变异分析
Phylogenetic and Genetic Variation Analysis of Porcine Epidemic Diarrhea Virus in East Central China during 2020-2023.
作者信息
Sun Liumei, Li Duo, Yan Caijie, Wu Chengyue, Han Feng, Bo Zongyi, Shen Manman, Sun Yiwei, Wang Liyan, Zheng Haoqin, Wang Mengdong, Zhang Zhendong
机构信息
Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China.
Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Scientific Research Center, Chinese Academy of Agricultural Sciences, Zhenjiang 212100, China.
出版信息
Animals (Basel). 2024 Jul 26;14(15):2185. doi: 10.3390/ani14152185.
Porcine epidemic diarrhea virus (PEDV) is a major causative pathogen of a highly contagious, acute enteric viral disease. This study evaluated the emergence of nine variants in Jiangsu and Anhui provinces of China from 2020 to 2023. S gene-based phylogenetic analysis indicated that three variants belong to the G1c subgroup, while the other six strains are clustered within the G2c subgroup. Recombination analyses supported that three variants of the G1c subgroup were likely derived from recombination of parental variants FR0012014 and a donor variant AJ1102. In addition, there are novel mutations on amino acid 141-148 and these likely resulted in changes in antigenicity in the three variants. These results illustrated that the study provides novel insights into the epidemiology, evolution, and transmission of PEDV in China.
猪流行性腹泻病毒（PEDV）是一种高度传染性急性肠道病毒性疾病的主要致病病原体。本研究评估了2020年至2023年中国江苏省和安徽省9个变异株的出现情况。基于S基因的系统发育分析表明，三个变异株属于G1c亚组，而其他六个毒株聚集在G2c亚组内。重组分析支持G1c亚组的三个变异株可能源自亲本变异株FR0012014和一个供体变异株AJ1102的重组。此外，在第141-148位氨基酸存在新的突变，这些突变可能导致这三个变异株的抗原性发生变化。这些结果表明，该研究为PEDV在中国的流行病学、进化和传播提供了新的见解。
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