The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma.

Gap junction protein beta 3 () has been reported as a tumor suppressor in most tumors. However, its role in lung adenocarcinoma (LUAD) remains unknown. The purpose of this study is to explore the role of in the prognosis and tumor microenvironment of LUAD patients. The data used in this study were acquired from The Cancer Genome Atlas, Gene Expression Omnibus, and imvigor210 cohorts. We found that expression was increased in LUAD patients and correlated with LUAD stages. LUAD patients with high expression exhibited a worse prognosis. A total of 164 pathways were significantly activated in the group. expression was positively associated with nine transcription factors and might be negatively regulated by hsa-miR-6511b-5p. Finally, we found that immune cell infiltration and immune checkpoint expression were different between the and groups. In summary. demonstrated high expression levels in LUAD patients, and those with elevated expression displayed unfavorable prognoses. Additionally, there was a correlation between and immune cell infiltration, as well as immune checkpoint expression in LUAD patients.