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三元环的高效合成:光化学和电化学策略。

The efficient synthesis of three-membered rings photo- and electrochemical strategies.

作者信息

Han Xinyu, Zhang Na, Li Qiannan, Zhang Yu, Das Shoubhik

机构信息

Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine No. 1200, Cailun Road Shanghai 201203 China

Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine Shanghai China.

出版信息

Chem Sci. 2024 Aug 14;15(34):13576-604. doi: 10.1039/d4sc02512a.

Abstract

Three-membered rings, such as epoxides, aziridines, oxaziridines, cyclopropenes, vinyloxaziridines, and azirines, are recognized as crucial pharmacophores and building blocks in organic chemistry and drug discovery. Despite the significant advances in the synthesis of these rings through photo/electrochemical methods over the past decade, there has currently been no focused discussion and updated overviews on this topic. Therefore, we presented this review article on the efficient synthesis of three-membered rings using photo- and electrochemical strategies, covering the literature since 2015. In this study, a conceptual overview and detailed discussions were provided to illustrate the advancement of this field. Moreover, a brief discussion outlines the current challenges and opportunities in synthesizing the three-membered rings using these strategies.

摘要

三元环,如环氧化物、氮丙啶、氧氮丙啶、环丙烯、乙烯基氧氮丙啶和氮杂环丙烯,被认为是有机化学和药物发现中至关重要的药效基团和结构单元。尽管在过去十年中通过光/电化学方法合成这些环取得了重大进展,但目前尚未有关于该主题的集中讨论和最新综述。因此,我们发表了这篇综述文章,介绍了使用光化学和电化学策略高效合成三元环的方法,涵盖了2015年以来的文献。在本研究中,提供了概念性概述和详细讨论,以说明该领域的进展。此外,还简要讨论了使用这些策略合成三元环目前面临的挑战和机遇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b74a/11351785/3c205eef2ea8/d4sc02512a-f1.jpg

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