非小细胞肺癌 G2 级患者中染色体 3p、5q、13q 和 21q 的特定缺失。

Specific Deletions of Chromosomes 3p, 5q, 13q, and 21q among Patients with G2 Grade of Non-Small Cell Lung Cancer.

机构信息

Department of Immunology, Poznan University of Medical Sciences, 60-806 Poznan, Poland.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.

出版信息

Int J Mol Sci. 2024 Aug 8;25(16):8642. doi: 10.3390/ijms25168642.

DOI:10.3390/ijms25168642

PMID:39201328

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11354976/

Abstract

Non-small cell lung cancer (NSCLC) leads as a primary cause of cancer-related premature mortality in Western populations. This study leverages cutting-edge gene-expression-profiling technologies to perform an in-depth molecular characterization of NSCLC specimens, with the objective of uncovering tumor-specific genomic alterations. By employing DNA microarray analysis, our research aims to refine the classification of NSCLC for early detection, guide molecular-targeted treatment approaches, enhance prognostication, and broaden the scientific understanding of the disease's biology. We identified widespread genomic abnormalities in our samples, including the recurrent loss of chromosomal regions 3p, 5q, 13q, and 21q and the gain of 12p. Furthermore, utilizing Metascape for bioinformatic analysis revealed critical biological pathways disrupted in NSCLC, offering promising leads for novel therapeutic interventions.

摘要

非小细胞肺癌（NSCLC）是西方人群中导致癌症相关过早死亡的主要原因。本研究利用最先进的基因表达谱分析技术，对 NSCLC 标本进行深入的分子特征描述，旨在揭示肿瘤特异性的基因组改变。通过 DNA 微阵列分析，我们的研究旨在改进 NSCLC 的早期检测分类，指导分子靶向治疗方法，提高预后预测，并加深对该疾病生物学的科学认识。我们在样本中发现了广泛的基因组异常，包括染色体区域 3p、5q、13q 和 21q 的反复缺失和 12p 的获得。此外，利用 Metascape 进行生物信息学分析揭示了 NSCLC 中关键的生物学途径受到破坏，为新的治疗干预提供了有前景的线索。