干眼病和良性特发性眼睑痉挛中眼睑压力和眼表面参数的比较：一项横断面研究。
Comparison of upper eyelid pressure and ocular surface parameters in dry eye disease and benign essential Blepharospasm: A cross-sectional study.
机构信息
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Bei-hang University and Capital Medical University, Beijing, China.
出版信息
Cont Lens Anterior Eye. 2024 Dec;47(6):102298. doi: 10.1016/j.clae.2024.102298. Epub 2024 Sep 14.
PURPOSE
To compare the upper eyelid pressure (UEP) and ocular surface parameters between dry eye disease (DED) and DED coexisting with benign essential blepharospasm (BEB), exploring which parameters could assist in distinguishing between DED and BEB, as potential risk factors for DED with BEB.
METHODS
All enrolled participants diagnosed with DED or DED coexisting with BEB were initially subjected to ocular surface disease index (OSDI) determination. Subsequently, the upper eyelid pressure was recorded using an innovative eyelid pressure measurement device, followed by a series of ocular surface examinations. The two groups were compared using the independent t-test and Mann-Whitney U test. A logistic regression analysis was performed to identify which parameters can predict the onset of blepharospasm.
RESULTS
The BEB group achieved a higher upper eyelid pressure (101.9 ± 23.5mN vs 88.4 ± 18.1mN, P = 0.009), lower number of total blink (6.2 ± 4.2 vs 7.1 ± 4.1, P = 0.016), higher corneal fluorescein staining score (4.0 ± 1.9 vs 3.0 ± 1.7, P = 0.046), higher partial blink rate (0.9 ± 0.2 vs 0.5 ± 0.4, P = 0.000) and the lower grade of meibum expressibility (1 (1, 2) vs 2 (1, 3), P = 0.000) and meibum quality (1 (1, 1) vs 1 (1, 1), P = 0.033) compared with the DED group. The upper eyelid pressure (OR = 1.123), partial blink rate (OR = 0.014) and the grade of meibum expressibility (OR = 10.804) showed significant associations with BEB (P < 0.05).
CONCLUSION
Despite similar OSDI scores, DED coexisting with BEB exhibited higher upper eyelid pressure, lower corneal fluorescein staining score, lower partial blink rate, more total blinks, lower grades of meibum expressibility, and lower meibum quality compared to DED alone. Among these, higher upper eyelid pressure, lower partial blink rate, and worse grade of meibum expressibility were identified as risk factors for BEB in DED.
目的
比较干眼症（DED）和 DED 合并良性特发性眼睑痉挛（BEB）患者的上睑压力（UEP）和眼表参数，探讨哪些参数有助于区分 DED 和 BEB，以及它们是否可能成为 DED 合并 BEB 的潜在风险因素。
方法
所有入组的 DED 或 DED 合并 BEB 患者均先进行眼表疾病指数（OSDI）测定，然后使用新型眼睑压力测量仪记录上睑压力，随后进行一系列眼表检查。采用独立样本 t 检验和 Mann-Whitney U 检验比较两组间的差异。采用 logistic 回归分析确定哪些参数可以预测眼睑痉挛的发生。
结果
BEB 组的上睑压力（101.9±23.5mN 比 88.4±18.1mN，P=0.009）更高，总眨眼次数（6.2±4.2 比 7.1±4.1，P=0.016）更少，角膜荧光素染色评分（4.0±1.9 比 3.0±1.7，P=0.046）更高，部分眨眼率（0.9±0.2 比 0.5±0.4，P=0.000）更高，睑板腺分泌物表达分级（1（1，2）比 2（1，3），P=0.000）和睑板腺分泌物质量（1（1，1）比 1（1，1），P=0.033）更低。上睑压力（OR=1.123）、部分眨眼率（OR=0.014）和睑板腺分泌物表达分级（OR=10.804）与 BEB 显著相关（P<0.05）。
结论
尽管 OSDI 评分相似，但与 DED 相比，DED 合并 BEB 患者的上睑压力更高，角膜荧光素染色评分更低，部分眨眼率更低，总眨眼次数更多，睑板腺分泌物表达分级更低，睑板腺分泌物质量更差。其中，上睑压力更高、部分眨眼率更低和睑板腺分泌物表达分级更差被确定为 DED 合并 BEB 的风险因素。
Zotero 插件