Plastic additives as a new threat to the global environment: Research status, remediation strategies and perspectives.

Discharge or leaching of plastic additives, which are an essential part of the plastic production process, can lead to environmental pollution with serious impacts on human and ecosystem health. Recently, the emission of plastic additives is increasing dramatically, but its pollution condition has not received enough attention. Meanwhile, the effective treatment strategy of plastic additive pollution is lack of systematic introduction. Therefore, it is crucial to analyze the harm and pollution status of plastic additives and explore effective pollution control strategies. This paper reviews the latest research progress on additives in plastics, describes the effects of their migration into packaged products and leaching into the environment, presents the hazards of four major classes of plastic additives (i.e., plasticizers, flame retardants, stabilizers, and antimicrobials), summarizes the existing abiotic/biotic strategies for accelerated the remediation of additives, and finally provides perspectives on future research on the removal of plastic additives. To the best of our knowledge, this is the first review that systematically analyzes strategies for the treatment of plastic additives. The study of these strategies could (i) provide feasible, cost-effective abiotic method for the removal of plastic additives, (ii) further enrich the current knowledge on plastic additive bioremediation, and (iii) present application and future development of plants, invertebrates and machine learning in plastic additive remediation.