Exploring Attention Bias Mechanisms in Sub-Threshold Depression: ERP Insights into Biased Orientation and Disengagement.

Individuals with depression may have alterations in attention that begin at the sub-threshold stage. This study explored attention bias from the perspectives of early attention orientation and late attention disengagement in individuals with sub-threshold depression (SD) and healthy control (HC) individuals using a cue-target paradigm and event-related potentials (ERPs). The study enrolled 46 participants, comprising 23 males and 23 females, with 25 individuals in the SD group and 21 in the HC group, exceeding the calculated sample size requirement. The data were analyzed from two aspects. Behavioral data showed that SD individuals had difficulty in attention disengagement and that the time of attention transfer was delayed. Analysis of ERP data revealed that, regardless of the attributes of the emotional stimulus, the cue information promoted participants' response to the target stimulus. While SD individuals did show directional acceleration of attention to the emotional stimulus, no significant negative attention bias was observed. Taken together, these findings suggest that SD individuals do not show specific directional acceleration of attention to negative stimuli in the early stage of attention processing, although there may be attention avoidance.