环状 RNA 调控与抑制性神经元中 ADARB2 富集的综合分析。

Integrated analysis of circRNA regulation with ADARB2 enrichment in inhibitory neurons.

机构信息

Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.

Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul National University, Seoul, Republic of Korea.

出版信息

Comput Biol Med. 2024 Nov;182:109212. doi: 10.1016/j.compbiomed.2024.109212. Epub 2024 Sep 28.

DOI:10.1016/j.compbiomed.2024.109212

PMID:39341111

Abstract

This study investigates the regulation of circular RNAs (circRNAs) with Adenosine Deaminase RNA Specific B2 (ADARB2) enrichment specifically in inhibitory neurons. Using an integrated analysis combining high-throughput sequencing and bioinformatics approaches, we identified a group of circRNAs that are potentially enhanced by ADARB2. Our findings highlight the pivotal role of ADARB2 in circRNA synthesis within inhibitory neurons, likely through its specific binding to precursor RNAs, which facilitates circRNA biogenesis.

摘要

本研究探讨了腺苷酸脱氨酶 RNA 特异性 B2（ADARB2）在抑制性神经元中特异性富集的环状 RNA（circRNAs）的调控作用。通过整合高通量测序和生物信息学方法的综合分析，我们鉴定出一组可能受 ADARB2 增强的 circRNAs。我们的研究结果强调了 ADARB2 在抑制性神经元中环状 RNA 合成中的关键作用，可能是通过其与前体 RNA 的特异性结合来促进 circRNA 的生物发生。