Chandanwale Rohan, Chandanwale Kshitija, Chandanwale Rutuja, Chandanwale Ajay
Orthopaedics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Surgery, Maharashtra Post Graduate Institute of Medical Education and Research, Nashik, IND.
Cureus. 2024 Aug 29;16(8):e68162. doi: 10.7759/cureus.68162. eCollection 2024 Aug.
Introduction Osteoporosis is one of the most prevalent bone diseases in humans and is a significant global public health issue since it is a risk factor for age-related fractures. Fracture risk is significantly influenced by bone mineral density (BMD). Recent research has revealed that there are various genetic and environmental variables that are similar between obesity and osteoporosis. The relationship between anthropometric measurements including weight, body surface area, height, and fat mass and BMD has been the subject of several studies. Decreased bone mass and a high risk of fracture have been linked to low BMI. Materials and methods A total of 370 female patients were included in this study. Anthropometric measures, such as weight and height, were taken in accordance with international standards. We measured the T-score, Speed of Sound (SOS) (in metres/s), Broadband Ultrasound Attenuation (BUA), and Stiffness Index (SI) of the participants using a portable quantitative ultrasonic bone densitometer with a gel-coupled system in a temperature-controlled environment (26 ± 1°C) to estimate the BMD. In this study, we analyzed the relationships between anthropometric measurements such as weight, height, BMI, and waist-hip ratio (WHR) and BMD. Results In our study, we found that the population falling under the categories of Underweight and Obese have shown to have reduced BMD. There is an association between normal BMI and normal BMD. BMI can considerably affect one's risk of developing osteoporosis. Therefore, BMI and weight can be used to screen those who are at risk of having osteoporosis and its associated problems. We also observed an association between menopause and BMD measured by Quantitative Ultrasound (QUS). In the study population, post-menopausal women had a 4 times higher risk of osteoporosis than pre-menopausal women (OR = 4.46). Conclusion Calcaneal QUS is potentially helpful as a pre-screening tool for the evaluation of osteoporosis, although it must be based on device-specific cut-offs that have been tested in the populations for which they are intended to be used in a pre-screen or stratification methodology.
引言
骨质疏松症是人类中最普遍的骨病之一,并且是一个重大的全球公共卫生问题,因为它是与年龄相关骨折的一个风险因素。骨折风险受骨密度(BMD)的显著影响。最近的研究表明,肥胖和骨质疏松症之间存在各种相似的遗传和环境变量。包括体重、体表面积、身高和脂肪量在内的人体测量学指标与骨密度之间的关系已成为多项研究的主题。骨量减少和高骨折风险与低体重指数(BMI)有关。
材料和方法
本研究共纳入370名女性患者。体重和身高等人的测量指标均按照国际标准进行。我们在温度控制环境(26±1°C)中使用带有凝胶耦合系统的便携式定量超声骨密度仪测量参与者的T值、声速(SOS)(米/秒)、宽带超声衰减(BUA)和刚度指数(SI),以估计骨密度。在本研究中,我们分析了体重、身高、BMI和腰臀比(WHR)等人体测量指标与骨密度之间的关系。
结果
在我们的研究中,我们发现体重过轻和肥胖类别的人群骨密度降低。正常BMI与正常骨密度之间存在关联。BMI会显著影响一个人患骨质疏松症的风险。因此,BMI和体重可用于筛查有患骨质疏松症及其相关问题风险的人群。我们还观察到绝经与通过定量超声(QUS)测量的骨密度之间存在关联。在研究人群中,绝经后女性患骨质疏松症的风险比绝经前女性高4倍(OR = 4.46)。
结论
跟骨定量超声作为骨质疏松症评估的预筛查工具可能有帮助,尽管它必须基于在其拟用于预筛查或分层方法的人群中经过测试的特定设备临界值。