40岁以下韩国绝经前女性的身高与乳腺癌风险
Height and breast cancer risk in premenopausal Korean women aged under 40 years of age.
作者信息
Tran Thi Xuan Mai, Chang Yoosoo, Choi Hye Rin, Kwon Ria, Lim Ga-Young, Cho Yoosun, Ryu Seungho, Park Boyoung
机构信息
Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Center for Cohort Studies, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
出版信息
Br J Cancer. 2024 Dec;131(12):1913-1918. doi: 10.1038/s41416-024-02846-w. Epub 2024 Oct 7.
BACKGROUND
Taller women are at an increased risk of breast cancer; however, evidence regarding this in younger women is limited. This study investigated the association between body height and breast cancer risk in premenopausal Korean women aged <40 years.
METHODS
Premenopausal women aged <40 years enroled in the Kangbuk Samsung Health Study (KSHS) and National Health Insurance Service-National Health Information Database (NHIS-NHID) were included in the analysis. Trained staff members performed anthropometry, including height measurements. Breast cancer incidence was followed up until December 2019. Cox regression model and restricted cubic- spline regression were applied.
RESULTS
The mean (standard deviation [SD]) age was 33.3 (3.6) years and 32.9 (4.2) in KSHS and NHIS-NHID cohorts, respectively. After adjusting for age at baseline and other confounders, every 10 cm of height was associated with a 1.44-fold increased risk of developing breast cancer (adjusted hazard ratio [aHR], 1.44; 95% confidence interval [CI], 1.17-1.78) in the KSHS. The restricted cubic spline regression showed an almost linear association between height and breast cancer risk. Compared to women with height <155 cm, aHRs (95% CI) among those with height 160-165 cm, 165-170 cm, and ≥170 cm were 1.67 (1.07-2.60), 1.75 (1.09-2.81), and 2.31 (1.18-3.86), respectively (P = 0.009). Results were similar in the NHIS-NHID cohort (aHR, 1.20 [95% CI, 1.10-1.31] per 10-cm increase in height).
CONCLUSION
In young Korean women, greater body height was associated with increased breast cancer risk.
背景
身材较高的女性患乳腺癌的风险增加；然而，关于年轻女性的这方面证据有限。本研究调查了年龄<40岁的绝经前韩国女性身高与乳腺癌风险之间的关联。
方法
纳入参加江北三星健康研究（KSHS）和国民健康保险服务-国民健康信息数据库（NHIS-NHID）的年龄<40岁的绝经前女性进行分析。训练有素的工作人员进行人体测量，包括身高测量。对乳腺癌发病率进行随访至2019年12月。应用Cox回归模型和限制性立方样条回归。
结果
KSHS队列和NHIS-NHID队列的平均（标准差[SD]）年龄分别为33.3（3.6）岁和32.9（4.2）岁。在对基线年龄和其他混杂因素进行调整后，身高每增加10厘米，KSHS队列中患乳腺癌的风险增加1.44倍（调整后危险比[aHR]，1.44；95%置信区间[CI]，1.17-1.78）。限制性立方样条回归显示身高与乳腺癌风险之间几乎呈线性关联。与身高<155厘米的女性相比，身高在160-165厘米、165-170厘米和≥170厘米的女性的aHR（95%CI）分别为1.67（1.07-2.60）、1.75（1.09-2.81）和2.31（1.18-3.86）（P=0.009）。NHIS-NHID队列的结果相似（身高每增加10厘米，aHR为1.20[95%CI，1.10-1.31]）。
结论
在年轻韩国女性中，较高的身高与乳腺癌风险增加相关。
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