晚期糖基化终末产物在大隐静脉移植失败中的作用。
The Role of Advanced Glycation End Products in Saphenous Vein Graft Failure.
作者信息
Akgümüş Alkame, Boyraz Bedrettin, Balun Ahmet
机构信息
Department of Cardiology, Faculty of Medicine, Bandırma Onyedi Eylül University, Balıkesir, Turkey.
Cardiology Department, Medicalpark Hospital, Mudanya University, Bursa, Turkey.
出版信息
Med Princ Pract. 2025;34(1):87-95. doi: 10.1159/000541879. Epub 2024 Oct 9.
OBJECTIVE
We aimed to investigate the relationship between advanced glycation end product (AGE) levels in patients with saphenous vein graft (SVG) failure and in patients without SVG failure.
SUBJECTS AND METHODS
In our study, 55 patients with a history of previous coronary artery bypass grafting (CABG) surgery, who subsequently underwent coronary angiography for any reason and were found to have either SVG occlusion or significant lesions, were included as study patients. Additionally, 55 patients who have had CABG surgery without SVG failure for at least 1 year served as the control group. AGE values of the patients were measured using the skin autofluorescence method.
RESULTS
In our study results, we observed a significant difference in AGE levels between the two groups of patients with similar demographic characteristics (SVG failure groups AGE 3.2 [2.8-3.6] vs. control groups AGE 2.4 [2.1-2.7] p < 0.001). In the receiver operating characteristic curve analysis, we determined the ability of AGE levels to detect SVG failure with an area under the curve of 0.869. We found that in patients with AGE >3, it could detect SVG failure with a sensitivity of 70.9% and a specificity of 87.3%.
CONCLUSIONS
Our results demonstrate that AGE levels can predict SVG failure risk inexpensively, easily, and quickly.
OBJECTIVE
We aimed to investigate the relationship between advanced glycation end product (AGE) levels in patients with saphenous vein graft (SVG) failure and in patients without SVG failure.
SUBJECTS AND METHODS
In our study, 55 patients with a history of previous coronary artery bypass grafting (CABG) surgery, who subsequently underwent coronary angiography for any reason and were found to have either SVG occlusion or significant lesions, were included as study patients. Additionally, 55 patients who have had CABG surgery without SVG failure for at least 1 year served as the control group. AGE values of the patients were measured using the skin autofluorescence method.
RESULTS
In our study results, we observed a significant difference in AGE levels between the two groups of patients with similar demographic characteristics (SVG failure groups AGE 3.2 [2.8-3.6] vs. control groups AGE 2.4 [2.1-2.7] p < 0.001). In the receiver operating characteristic curve analysis, we determined the ability of AGE levels to detect SVG failure with an area under the curve of 0.869. We found that in patients with AGE >3, it could detect SVG failure with a sensitivity of 70.9% and a specificity of 87.3%.
CONCLUSIONS
Our results demonstrate that AGE levels can predict SVG failure risk inexpensively, easily, and quickly.
目的
我们旨在研究大隐静脉移植血管（SVG）功能衰竭患者与无SVG功能衰竭患者体内晚期糖基化终末产物（AGE）水平之间的关系。
受试者与方法
在我们的研究中，纳入了55例既往有冠状动脉旁路移植术（CABG）病史的患者，这些患者随后因任何原因接受了冠状动脉造影，且被发现存在SVG闭塞或严重病变，作为研究对象。此外，55例接受了CABG手术且至少1年无SVG功能衰竭的患者作为对照组。采用皮肤自发荧光法测量患者的AGE值。
结果
在我们的研究结果中，我们观察到两组具有相似人口统计学特征的患者之间AGE水平存在显著差异（SVG功能衰竭组AGE为3.2[2.8 - 3.6]，对照组AGE为2.4[2.1 - 2.7]，p < 0.001）。在受试者工作特征曲线分析中，我们确定AGE水平检测SVG功能衰竭的能力，曲线下面积为0.869。我们发现，在AGE>3的患者中，其检测SVG功能衰竭的灵敏度为70.9%，特异性为87.3%。
结论
我们的结果表明，AGE水平能够廉价、简便且快速地预测SVG功能衰竭风险。
目的
我们旨在研究大隐静脉移植血管（SVG）功能衰竭患者与无SVG功能衰竭患者体内晚期糖基化终末产物（AGE）水平之间的关系。
受试者与方法
在我们的研究中，纳入了55例既往有冠状动脉旁路移植术（CABG）病史的患者，这些患者随后因任何原因接受了冠状动脉造影，且被发现存在SVG闭塞或严重病变，作为研究对象。此外，55例接受了CABG手术且至少1年无SVG功能衰竭的患者作为对照组。采用皮肤自发荧光法测量患者的AGE值。
结果
在我们的研究结果中，我们观察到两组具有相似人口统计学特征的患者之间AGE水平存在显著差异（SVG功能衰竭组AGE为3.2[2.8 - 3.6]，对照组AGE为2.4[2.1 - 2.7]，p < 0.001）。在受试者工作特征曲线分析中，我们确定AGE水平检测SVG功能衰竭的能力，曲线下面积为0.869。我们发现，在AGE>3的患者中，其检测SVG功能衰竭的灵敏度为70.9%，特异性为87.3%。
结论
我们的结果表明，AGE水平能够廉价、简便且快速地预测SVG功能衰竭风险。
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