在气流受限的个体中，表观遗传年龄较小与较高的心肺适能相关。
Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation.
作者信息
Hernandez Cordero Ana I, Peters Carli, Li Xuan, Yang Chen Xi, Ambalavanan Amirthagowri, MacIsaac Julie L, Kobor Michael S, Fonseca Gregory J, Doiron Dany, Tan Wan, Bourbeau Jean, Jensen Dennis, Sin Don D, Koelwyn Graeme J, Stickland Michael K, Duan Qingling, Leung Janice M
机构信息
Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.
Edwin S. H. Leong Healthy Aging Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
出版信息
iScience. 2024 Sep 13;27(10):110934. doi: 10.1016/j.isci.2024.110934. eCollection 2024 Oct 18.
We hypothesized that increased cardiorespiratory fitness (CRF) slows down a person's aging, particularly in individuals with chronic airflow limitation (CAL). Participants aged ≥40 years ( = 78) had baseline blood DNA methylation profiled and underwent cardiopulmonary cycle exercise testing at baseline and at three years. Epigenetic clocks were calculated and tested for their association with CRF using linear regression. Differentially methylated genes associated with CRF were identified using a robust linear model. Higher CRF at baseline was associated with lower age acceleration in the epigenetic clocks DNAmAgeSkinBlood (), DNAmGrimAge (), and DNAmGrimAge2 (). These effects were consistent in individuals with CAL (DNAmGrimAge and DNAmGrimAge2 ). CRF at three years was associated with baseline DNAmGrimAge () and DNAmGrimAge2 (). Differentially methylated genes associated with CRF enriched multiple aging-related pathways, including cellular senescence. Enhancing CRF may be one intervention that can slow biological aging and improve health outcomes in chronic respiratory diseases.
我们假设，提高心肺适能（CRF）可减缓人的衰老，尤其是在患有慢性气流受限（CAL）的个体中。年龄≥40岁的参与者（n = 78）进行了基线血液DNA甲基化分析，并在基线和三年时接受了心肺循环运动测试。使用线性回归计算表观遗传时钟并测试其与CRF的关联。使用稳健线性模型鉴定与CRF相关的差异甲基化基因。基线时较高的CRF与表观遗传时钟DNAmAgeSkinBlood（p = 0.002）、DNAmGrimAge（p = 0.003）和DNAmGrimAge2（p = 0.006）中较低的年龄加速相关。这些效应在患有CAL的个体中是一致的（DNAmGrimAge p = 0.012和DNAmGrimAge2 p = 0.002）。三年时的CRF与基线DNAmGrimAge（p = 0.004）和DNAmGrimAge2（p = 0.003）相关。与CRF相关的差异甲基化基因富集了多个与衰老相关的途径，包括细胞衰老。提高CRF可能是一种可以减缓生物衰老并改善慢性呼吸道疾病健康结局的干预措施。
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