作为结核病疫苗研发中变革性因素的保护性免疫相关指标。
Immune correlates of protection as a game changer in tuberculosis vaccine development.
作者信息
Wang Jing, Fan Xiao-Yong, Hu Zhidong
机构信息
Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, 201508, China.
出版信息
NPJ Vaccines. 2024 Oct 30;9(1):208. doi: 10.1038/s41541-024-01004-w.
The absence of validated correlates of protection (CoPs) hampers the rational design and clinical development of new tuberculosis vaccines. In this review, we provide an overview of the potential CoPs in tuberculosis vaccine research. Major hindrances and potential opportunities are then discussed. Based on recent progress, it is reasonable to anticipate that success in the ongoing efforts to identify CoPs would be a game-changer in tuberculosis vaccine development.
缺乏经过验证的保护关联指标（CoP）阻碍了新型结核病疫苗的合理设计和临床开发。在本综述中，我们概述了结核病疫苗研究中的潜在保护关联指标。然后讨论了主要障碍和潜在机遇。基于最近的进展，有理由预计，在正在进行的确定保护关联指标的工作中取得成功将成为结核病疫苗开发的一个改变局面的因素。
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