单核细胞与高密度脂蛋白胆固醇比值与端粒长度的关系：基于 NHANES 1999-2002。

Association between monocyte to high-density lipoprotein cholesterol ratio and telomere length: based on NHANES 1999-2002.

机构信息

Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, 315100, China.

Department of Cardiovascular Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, 315100, China.

出版信息

BMC Cardiovasc Disord. 2024 Nov 4;24(1):616. doi: 10.1186/s12872-024-04301-3.

DOI:10.1186/s12872-024-04301-3

PMID:39497037

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11533404/

Abstract

BACKGROUND

Telomere length is closely associated with the occurrence and development of cardiovascular and other diseases. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel indicator of inflammation, oxidative stress, and metabolic syndrome, with some predictive ability for related disease risks in clinical practice. However, there is no research on the correlation between these two factors.

METHODS

Using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2002, we conducted analysis and research on the correlation between MHR and telomere length using the Kruskal-Wallis H test, Spearman rank correlation analysis, and partial correlation analysis. Weighted linear regression analysis assessed the strength of the association between the two variables, while restricted cubic spline regression (RCS) explored potential nonlinear relationships between them.

RESULTS

The results of correlation analysis showed that MHR levels were negatively correlated with telomere length (ρ=-0.083, P < 0.001), and this relationship remained statistically significant after controlling for other covariates (P all < 0.001). Weighted linear regression analysis showed that after adjusting for all covariates, MHR remained negatively associated with telomere length (β = -0.020; 95% CI: -0.039 to -0.002; P = 0.037). Subgroup analysis shows that the negative association between MHR and telomere length appeared more striking among females (𝛽 = -0.024; 95%CI: -0.050 to 0.001; P = 0.058), the Non-Hispanic White (𝛽 = -0.022; 95%CI: -0.045 to 0.002; P = 0.066), and other race (𝛽 = -0.067; 95%CI: -0.134 to -0.000; P = 0.049). Using RCS explored potential nonlinear relationships between MHR and telomere length, revealing no nonlinear relationship between the two (P = 0.102).

CONCLUSIONS

This study suggests a negative correlation between MHR levels and telomere length in American adults. More comprehensive research is needed to confirm these findings in the future.

摘要

背景

端粒长度与心血管疾病和其他疾病的发生和发展密切相关。单核细胞与高密度脂蛋白胆固醇比值（MHR）是一种新的炎症、氧化应激和代谢综合征指标，在临床实践中对相关疾病风险具有一定的预测能力。然而，目前还没有关于这两个因素之间相关性的研究。

方法

利用 1999 年至 2002 年全国健康和营养检查调查（NHANES）的数据，采用 Kruskal-Wallis H 检验、Spearman 秩相关分析和偏相关分析，对 MHR 与端粒长度之间的相关性进行分析研究。加权线性回归分析评估了两个变量之间关联的强度，而限制立方样条回归（RCS）则探索了它们之间潜在的非线性关系。

结果

相关性分析结果表明，MHR 水平与端粒长度呈负相关（ρ=-0.083，P<0.001），且在控制其他协变量后仍具有统计学意义（P 均<0.001）。加权线性回归分析表明，在调整所有协变量后，MHR 与端粒长度仍呈负相关（β=-0.020；95%CI：-0.039 至-0.002；P=0.037）。亚组分析显示，在女性（β=-0.024；95%CI：-0.050 至 0.001；P=0.058）、非西班牙裔白人（β=-0.022；95%CI：-0.045 至 0.002；P=0.066）和其他种族（β=-0.067；95%CI：-0.134 至-0.000；P=0.049）中，MHR 与端粒长度之间的负相关更为显著。使用 RCS 探索 MHR 与端粒长度之间潜在的非线性关系，结果显示两者之间无非线性关系（P=0.102）。