非洲脑肿瘤联盟的成立：推动非洲脑肿瘤的合作研究与宣传。
Establishment of a brain tumor consortium of Africa: Advancing collaborative research and advocacy for brain tumors in Africa.
作者信息
Odukoya Lateef A, Darko Kwadwo, Zerd Francis, Ghomsi Nathalie C, Kabare Gloria, Kamson David O, Eckel-Passow Jeanette E, Jenkins Robert B, Kitange Gaspar J, Akinjo Andrea O, Badmos Kabir B, Bankole Olufemi, Idowu Olufemi E, Karekezi Claire, Edrick Elias, Ekhator Chukwuyem, Katasi Victoria M, Brown Desmond A, Huse Jason, Llewellyn Henry, Magambo Margreth, Magoha Michael, Barrie Umaru, Ngaiza Advera, Nyalundja Arsene D, Okemwa Minda, Osei-Tutu Lawrence, Petershie Bernard, Yevudza W Elorm, Anunobi Charles C, Tiamiyu Liadi, Gankpe Gbetoho Fortuné, Heronima Kashaigili, Higgins Dominique, Schroeder Kristin, Totimeh Teddy, Balogun James, Cheserem Beverly, Etame Arnold B, Fonkem Ekokobe
机构信息
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, New York, USA.
Department of Neurosurgery, Korle-Bu Teaching Hospital, Accra, Ghana.
出版信息
Neurooncol Adv. 2024 Nov 16;6(1):vdae198. doi: 10.1093/noajnl/vdae198. eCollection 2024 Jan-Dec.
BACKGROUND
Brain tumors represent a significant global health challenge, with rising incidence and mortality impacting individuals worldwide and contributing to cancer-related morbidity and mortality. In Africa, this burden is exacerbated by limited access to advanced diagnostics, treatment options, and multidisciplinary care, compounded by the absence of standardized cancer registration and tumor biobanking. The introduction of molecular diagnostics, as outlined in the 2021 World Health Organization central nervous system (CNS) tumor classification, adds complexity to brain tumor management, particularly in regions with scarce resources.
METHODS
To address these issues, the Brain Tumor Consortium for Africa (BTCA) was established in 2023, bringing together experts to improve CNS tumor diagnosis, patient care, and research. The initial project, conducted via an electronic questionnaire, aimed to assess neuro-oncology capacity across Sub-Saharan Africa.
RESULTS
The study revealed significant gaps, with a limited number of institutions incorporating molecular subtyping into their diagnostic algorithms. The consortium's efforts focus on enhancing local data use, informing public policy, and promoting collaboration to advance neuro-oncology practices in Africa. By fostering a network enlisting the expertise of collaborators in the fields of neurosurgery, neurology, neuropathology, anatomic pathology, and medical and radiation oncology, the BTCA seeks to improve brain tumor management through better diagnostics, infrastructure, and policy advocacy. Future directions include expanding molecular diagnostic capabilities, standardizing brain tumor biobanking, enhancing data collection, and advocating for improved brain tumor care in national health agendas.
CONCLUSIONS
The BTCA represents a pioneering model of collaboration and innovation in addressing the unique challenges of brain tumor care in Africa.
背景
脑肿瘤是一项重大的全球健康挑战，其发病率和死亡率不断上升，影响着世界各地的个人，并导致与癌症相关的发病和死亡。在非洲，由于获得先进诊断、治疗选择和多学科护理的机会有限，以及缺乏标准化的癌症登记和肿瘤生物样本库，这一负担更加沉重。如2021年世界卫生组织中枢神经系统（CNS）肿瘤分类中所概述的，分子诊断的引入增加了脑肿瘤管理的复杂性，尤其是在资源匮乏的地区。
方法
为了解决这些问题，非洲脑肿瘤联盟（BTCA）于2023年成立，汇集专家以改善中枢神经系统肿瘤的诊断、患者护理和研究。通过电子问卷进行的初始项目旨在评估撒哈拉以南非洲的神经肿瘤学能力。
结果
研究发现了重大差距，将分子亚型纳入其诊断算法的机构数量有限。该联盟的努力集中在加强本地数据利用、为公共政策提供信息以及促进合作，以推进非洲的神经肿瘤学实践。通过建立一个网络，招募神经外科、神经病学、神经病理学、解剖病理学以及医学和放射肿瘤学领域的合作者的专业知识，BTCA寻求通过更好的诊断、基础设施和政策倡导来改善脑肿瘤管理。未来的方向包括扩大分子诊断能力、标准化脑肿瘤生物样本库、加强数据收集以及在国家卫生议程中倡导改善脑肿瘤护理。
结论
BTCA是应对非洲脑肿瘤护理独特挑战的合作与创新的开创性模式。
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