长链非编码RNA在癌细胞中陪伴动态蛋白质凝聚物

LncRNAs chaperoning dynamic protein condensates in cancer cells.

作者信息

Hu Jiaojiao, Li Dan, Liu Cong

机构信息

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.

出版信息

Mol Cell. 2024 Dec 19;84(24):4695-4697. doi: 10.1016/j.molcel.2024.11.028.

DOI:10.1016/j.molcel.2024.11.028

PMID:39706163

Abstract

In this issue of Molecular Cell, Sun et al. reveal that the long non-coding RNA (lncRNA) DNAJC3-AS1 plays a dual role in maintaining the rRNA processing function of fibrillarin (FBL) in cancer cells. It promotes FBL condensation while preventing abnormal aggregation, offering new therapeutic insights for cancer treatment by targeting lncRNAs involved in the regulation of FBL condensation.

摘要

在本期《分子细胞》杂志中，孙等人揭示了长链非编码RNA（lncRNA）DNAJC3-AS1在维持癌细胞中纤维蛋白原（FBL）的核糖体RNA加工功能方面发挥双重作用。它促进FBL凝聚，同时防止异常聚集，通过靶向参与FBL凝聚调节的lncRNAs为癌症治疗提供了新的治疗思路。