多胺：免疫代谢和免疫调节中的关键参与者。
Polyamines: Key Players in Immunometabolism and Immune Regulation.
作者信息
Mahalingam Shanmuga S, Pandiyan Pushpa
机构信息
Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
出版信息
J Cell Immunol. 2024;6(5):196-208. doi: 10.33696/immunology.6.206.
Polyamines are small organic molecules ubiquitously present in all living organisms and function as crucial regulators of biological processes ranging from fundamental cellular metabolism to immune regulation. Dysregulation of polyamine metabolism has been implicated in numerous diseases, including neurodegenerative disorders, inflammatory conditions, autoimmune diseases, and cancer. This review provides an overview of pathophysiology of these conditions, highlighting polyamines' role in immunometabolic alterations in the context of immune regulation. Exploring the intricate mechanisms of polyamine metabolism holds promise for advancing our understanding of disease processes and developing potential innovative therapeutic interventions.
多胺是普遍存在于所有生物体中的小分子有机化合物，在从基本细胞代谢到免疫调节等一系列生物过程中发挥着关键调节作用。多胺代谢失调与多种疾病有关，包括神经退行性疾病、炎症性疾病、自身免疫性疾病和癌症。本综述概述了这些疾病的病理生理学，强调了多胺在免疫调节背景下免疫代谢改变中的作用。探索多胺代谢的复杂机制有望增进我们对疾病过程的理解，并开发潜在的创新治疗干预措施。
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