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组学技术进展:急性肺损伤和急性呼吸窘迫综合征的分子机制(综述)

Advancements in omics technologies: Molecular mechanisms of acute lung injury and acute respiratory distress syndrome (Review).

作者信息

Zheng Zhihuan, Qiao Xinyu, Yin Junhao, Kong Junjie, Han Wanqing, Qin Jing, Meng Fanda, Tian Ge, Feng Xiujing

机构信息

Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China.

Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China.

出版信息

Int J Mol Med. 2025 Mar;55(3). doi: 10.3892/ijmm.2024.5479. Epub 2025 Jan 3.

Abstract

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response arising from lung and systemic injury with diverse causes and associated with high rates of morbidity and mortality. To date, no fully effective pharmacological therapies have been established and the relevant underlying mechanisms warrant elucidation, which may be facilitated by multi‑omics technology. The present review summarizes the application of multi‑omics technology in identifying novel diagnostic markers and therapeutic strategies of ALI/ARDS as well as its pathogenesis.

摘要

急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)是一种由肺部和全身损伤引发的炎症反应,病因多样,且发病率和死亡率很高。迄今为止,尚未建立完全有效的药物治疗方法,相关的潜在机制有待阐明,而多组学技术可能有助于这一过程。本综述总结了多组学技术在识别ALI/ARDS的新型诊断标志物、治疗策略及其发病机制方面的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b276/11722059/e7b23ab56630/ijmm-55-03-05479-g00.jpg

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