单细胞RNA测序突显了宫颈小细胞神经内分泌癌独特的肿瘤微环境。

Single-cell RNA sequencing highlights the unique tumor microenvironment of small cell neuroendocrine cervical carcinoma.

作者信息

Wang Tianyou, Zhang Li, Mei Song, Wang Bo, Liu Jiaqi, Yang Weiping, Liao Jiongbo, Wang Chao

机构信息

Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

J Transl Med. 2025 Jan 6;23(1):19. doi: 10.1186/s12967-024-05977-z.

DOI:10.1186/s12967-024-05977-z

PMID:39762893

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11702138/

Abstract

Small cell neuroendocrine cervical carcinoma is a highly aggressive tumor characterized by early metastasis, a high recurrence rate, and poor prognosis. This study represents the first instance of single-cell sequencing conducted on small cell neuroendocrine carcinoma of the cervix worldwide. Analysis of gene expression regulatory networks revealed that the transcription factor TFF3 drived up-regulation of ELF3. Furthermore, our findings indicated that the neuroendocrine marker genes and gene regulatory networks associated with small cell neuroendocrine cervical carcinoma differed from those observed in lung, small intestine, and liver neuroendocrine carcinoma within the GEO database, suggesting tissue-specific origins for these malignancies. Overall, this study addresses a significant research in understanding small cell neuroendocrine cervical carcinoma in vivo and provides valuable insights for guiding radiotherapy, chemotherapy, and targeted therapy.

摘要

小细胞神经内分泌宫颈癌是一种侵袭性很强的肿瘤，其特点是早期转移、复发率高且预后差。本研究是全球首次对宫颈小细胞神经内分泌癌进行单细胞测序。基因表达调控网络分析显示，转录因子TFF3驱动ELF3上调。此外，我们的研究结果表明，与宫颈小细胞神经内分泌癌相关的神经内分泌标记基因和基因调控网络与GEO数据库中肺、小肠和肝神经内分泌癌中观察到的不同，提示这些恶性肿瘤具有组织特异性起源。总体而言，本研究为理解体内宫颈小细胞神经内分泌癌提供了一项重要研究，并为指导放疗、化疗和靶向治疗提供了有价值的见解。