Recent advances in lipid-based nanocarriers for advanced skin cancer therapy.

Skin cancer is prevalent worldwide,surpassing all other forms of cancer and it does not respond effectively to conventional formulations. Treatment of skin cancer further require deeper permeation into the skin. Therefore, researchers are working on different types of nanoformulations for delivering therapeutic agents to the site of action. Amongst, lipid-based nanoparticles have shown potential for the efficient delivery of drugs to skin tumors, where properties like biocompatible, non-toxic, and biodegradable have attracted researcher concern. The literature revealed that these lipid-mediated nanocarriers with a size < 100 nm treats skin cancer efficiently and surmount resistance by increasing the solubility and stability of the hydrophobic chemotherapeutics. These lipid nanocarriers are safer for topical application and facilitate permeation through the skin by interacting with the lipid bilayer membranes, resulting in rearrangement of them to promote penetration into the cells. This review discussed the research done so far to treat skin cancer with lipid-based nanocarriers. These nanocarriers can be effective tools, which can be explored and established further to combat the increasing incidences of skin cancer in the future.