唾液腺干细胞/祖细胞：从基础科学迈向临床应用

Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.

作者信息

Langthasa Jimpi, Guan Li, Jinagal Shyam Lal, Le Quynh-Thu

机构信息

Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Dr Clinic D, Stanford, CA, MC 584794305, USA.

Gladstone Institutes, San Francisco, CA, USA.

出版信息

Cell Regen. 2025 Jan 24;14(1):4. doi: 10.1186/s13619-025-00221-5.

DOI:10.1186/s13619-025-00221-5

PMID:39856475

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11759724/

Abstract

Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren's syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, and their role in tissue regeneration. Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions.

摘要

唾液腺干/祖细胞（SSPCs）在再生医学中具有巨大潜力，尤其对于因放疗、干燥综合征和衰老等各种原因导致唾液腺功能障碍的患者。本综述全面概述了SSPCs，包括其特征、分离、培养技术、分化途径及其在组织再生中的作用。此外，我们强调了基于细胞和组织的疗法的最新进展，如SSPC移植和生物工程器官替代。还讨论了将SSPC研究转化为有效临床治疗面临的挑战，以及提出的解决方案和未来研究方向。