上呼吸道和上消化道鳞状细胞癌：生物学、遗传学与治疗的统一视角
Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy.
作者信息
Henick Brian S, Taylor Alison M, Nakagawa Hiroshi, Wong Kwok-Kin, Diehl J Alan, Rustgi Anil K
机构信息
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Division of Hematology-Oncology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
出版信息
Cancer Cell. 2025 Feb 10;43(2):178-194. doi: 10.1016/j.ccell.2025.01.003.
Squamous cell cancers (SCCs) of the head and neck, esophagus, and lung, referred to as aero-upper digestive SCCs, are prevalent in the United States and worldwide. Their incidence and mortality are projected to increase at alarming rates, posing diagnostic, prognostic, and therapeutic challenges. These SCCs share certain epigenetic, genomic, and genetic alterations, immunologic properties, environmental exposures, as well as lifestyle and nutritional risk factors, which may underscore common complex gene-environmental interactions across them. This review focuses upon the frequent shared epigenetic, genomic, and genetic alterations, emerging preclinical model systems, and how this collective knowledge can be leveraged into perspectives on standard of care therapies and mechanisms of resistance, nominating new potential directions in translational therapeutics.
头颈部、食管和肺部的鳞状细胞癌（SCC），即所谓的上呼吸道消化道SCC，在美国和全球都很常见。预计它们的发病率和死亡率将以惊人的速度上升，带来诊断、预后和治疗方面的挑战。这些SCC具有某些表观遗传、基因组和基因改变、免疫特性、环境暴露以及生活方式和营养风险因素，这可能突出了它们之间常见的复杂基因-环境相互作用。本综述重点关注频繁共有的表观遗传、基因组和基因改变、新兴的临床前模型系统，以及如何将这些共同知识应用于护理标准疗法和耐药机制的观点，为转化治疗提名新的潜在方向。
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