通过两样本孟德尔随机化和整合转录组-蛋白质组分析鉴定肝细胞癌中的因果血浆蛋白
Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-Sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis.
作者信息
Tang Weihao, Ma Xiaoke
机构信息
College of Liberal Arts and Sciences, University of Florida, Gainesville, Florida.
School of Computer Science and Technology, Xidian University, Xi'an, China.
出版信息
Cancer Res Commun. 2025 Mar 1;5(3):433-443. doi: 10.1158/2767-9764.CRC-24-0553.
Abstract
In this study, we identified several causal proteins in HCC using UK Biobank Pharma Proteomics Project proteomic data via two-sample MR. We performed colocalization and sensitivity analyses, utilized single-cell RNA sequencing data for validation, and discovered potential drugs through molecular docking.
摘要
在本研究中，我们通过两样本孟德尔随机化分析，利用英国生物银行药物蛋白质组学项目的蛋白质组学数据，在肝癌中鉴定出了几种因果蛋白。我们进行了共定位和敏感性分析，利用单细胞RNA测序数据进行验证，并通过分子对接发现了潜在药物。
Zotero 插件