有氧运动干预对认知功能的纵向蛋白质组学分析
Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention.
作者信息
Donald Alison M H, de Almeida Luiz G N, Dabaja Mohamed Ziad, Orchard Isabella, Ybema Kaia, Tsegai Veronica, Armstrong Victoria, Smith Sophie, Young Daniel, Longman Richard Stewart, Tyndall Amanda V, Rawling Jean M, Hill Michael D, Tsai Willis H, Agbani Ejaife, Poulin Marc J, Dufour Antoine
机构信息
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
出版信息
Ann Neurol. 2025 May;97(5):1007-1018. doi: 10.1002/ana.27210. Epub 2025 Feb 27.
The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators. In our cohort, SERPINF1 is associated with greater maximal oxygen uptake after an aerobic exercise intervention. Sleep quality is also a key factor in relation to inter-alpha-trypsin inhibitor heavy chain H2, which was associated with greater sleep efficiency. Additionally, we validate that the coagulation profile of decliners' plasma contains procoagulant agonists, leading to greater platelet activation. ANN NEUROL 2025;97:1007-1018.
认知衰退的生理基础在很大程度上仍未得到明确。我们在在世人类中确定了一组蛋白质特征，其与5年期间神经认知功能的改善相关。我们的特征由补体蛋白、凝血级联反应和细胞外基质调节因子组成。在我们的队列中，SERPINF1与有氧运动干预后更大的最大摄氧量相关。睡眠质量也是与α-胰蛋白酶抑制剂重链H2相关的一个关键因素，该蛋白与更高的睡眠效率相关。此外，我们证实衰退者血浆的凝血特征含有促凝血激动剂，导致更大程度的血小板活化。《神经病学年鉴》2025年；97:1007 - 1018。
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