骨科患者出院后阿片类药物使用模式被低估：一项探索性研究。
Post-discharge opioid utilization patterns in orthopedic patients are underestimated: an explorative study.
作者信息
Hendrickx Sanne A M, Landman Ellie B M, Kleinlugtenbelt Ydo V
机构信息
Department of Orthopaedic and Trauma Surgery, Deventer Ziekenhuis, SE Deventer, the Netherlands.
出版信息
Pain Manag. 2025 Apr;15(4):199-204. doi: 10.1080/17581869.2025.2473871. Epub 2025 Mar 2.
AIM
This study explores morphine use among patients after discharge following total hip (THA) or knee arthroplasty (TKA).
METHOD
Morphine use was monitored for 14 days post-discharge. Patients recorded their morphine intake and reported pain using a Visual Analog Scale (VAS). Incomplete reports were excluded from longitudinal analysis. Median tablet count and total morphine use in milligram equivalents (MME) were calculated. Patients were categorized as non-users (0 mmE), short-term users (<100 mmE), and consistent users (>100 mmE).
RESULTS
Of the 67 patients, six dropped out. Among the remaining, 22 (36.7%) took no morphine, while 38 (63.3%) took at least one dose, with a median VAS-score of 5. Short-term users ( = 19) averaged a total of 40 mmE, mainly in the first three days, while consistent users ( = 15) averaged in total 220 mmE during follow-up, tapering gradually. After 14 days, 3% continued usage. Four patients with incomplete data were excluded. However, for those was found that this was due to or related to the fact that they used a large amount of morphine.
CONCLUSION
Most patients used minimal or no morphine, tapering off within two weeks.
目的
本研究探讨全髋关节置换术（THA）或膝关节置换术（TKA）出院后患者的吗啡使用情况。
方法
出院后14天监测吗啡使用情况。患者记录吗啡摄入量，并使用视觉模拟量表（VAS）报告疼痛程度。纵向分析排除报告不完整的患者。计算吗啡片数中位数及以毫克当量（MME）计的吗啡总使用量。将患者分为非使用者（0毫克当量）、短期使用者（<100毫克当量）和持续使用者（>100毫克当量）。
结果
67例患者中，6例退出。其余患者中，22例（36.7%）未服用吗啡，38例（63.3%）至少服用一剂，VAS评分中位数为5。短期使用者（n = 19）平均总用量为40毫克当量，主要在前三天，而持续使用者（n = 1
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