Wu Ruicheng, Zhu Weizhen, Shao Fanglin, Wang Jie, Li Dengxiong, Tuo Zhouting, Yoo Koo Han, Wusiman Dilinaer, Shu Ziyu, Ge Wenjing, Yang Yubo, Ke Mang, Wei Wuran, Heavey Susan, Cho William C, Feng Dechao
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Radiol Med. 2025 Mar 5. doi: 10.1007/s11547-025-01971-7.
Theragnostics is the integration of treatment and diagnosis, involving a drug or technology that combines diagnostic imaging with targeted therapy. This approach utilizes imaging to identify specific biological targets, which are then used to deliver therapeutic effects for the benefit of patients. The effectiveness and potential of theragnostics in improving patient outcomes are supported by significant clinical trials and technological innovations. Theragnostics has demonstrated its capacity to deliver targeted and real-time interventions, making it adaptable to diverse clinical domains. Its applications range from visualizing and eradicating tumors to addressing complex neurological disorders and cardiovascular diseases. The integration of nanomaterials and advancements in molecular biology further enhance the capabilities of theragnostics, promising a future where treatments are highly personalized, and diseases are understood and managed at a molecular level previously unattainable. Our comprehensive overview focuses on the current advancements in theragnostics applications across different disease domains. We highlight the role of molecular imaging technologies, such as PET/CT scans, in early diagnosis and treatment. Additionally, we explore the potential of chemokines as molecular imaging targets in systemic inflammatory diseases and central nervous system pathologies. In conclusion, the progression of theragnostics represents a transformative phase in medical practice, providing new avenues for precise treatment and improved patient outcomes. Its multidisciplinary nature and continuous innovation have the potential to profoundly impact the future of medical research and clinical practice, as well as revolutionizing the treatment and management of a wide array of diseases.
治疗诊断学是治疗与诊断的结合,涉及一种将诊断成像与靶向治疗相结合的药物或技术。这种方法利用成像来识别特定的生物靶点,然后利用这些靶点产生治疗效果,以造福患者。重大的临床试验和技术创新证明了治疗诊断学在改善患者预后方面的有效性和潜力。治疗诊断学已证明其能够提供靶向和实时干预,使其适用于各种临床领域。其应用范围从可视化和根除肿瘤到治疗复杂的神经系统疾病和心血管疾病。纳米材料的整合和分子生物学的进步进一步增强了治疗诊断学的能力,预示着一个未来,即治疗将高度个性化,疾病将在以前无法达到的分子水平上得到理解和管理。我们的全面概述聚焦于治疗诊断学在不同疾病领域应用的当前进展。我们强调分子成像技术,如PET/CT扫描,在早期诊断和治疗中的作用。此外,我们探讨趋化因子作为全身炎症性疾病和中枢神经系统疾病分子成像靶点的潜力。总之,治疗诊断学的发展代表了医学实践中的一个变革阶段,为精准治疗和改善患者预后提供了新途径。其多学科性质和持续创新有可能深刻影响医学研究和临床实践的未来,并彻底改变多种疾病的治疗和管理方式。