传染性的起始解释了结核分枝杆菌各谱系间传播性的差异。

Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages.

作者信息

Windels Etthel M, Valenzuela Agüí Cecilia, de Jong Bouke C, Meehan Conor J, Loiseau Chloé, Goig Galo A, Zwyer Michaela, Borrell Sonia, Brites Daniela, Gagneux Sebastien, Stadler Tanja

机构信息

ETH Zürich, Basel, Switzerland; Swiss Tropical and Public Health Institute, Allschwil, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.

ETH Zürich, Basel, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.

出版信息

Epidemics. 2025 Jun;51:100821. doi: 10.1016/j.epidem.2025.100821. Epub 2025 Mar 11.

DOI:10.1016/j.epidem.2025.100821

PMID:40118009

Abstract

Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability have not been studied in detail. Here, we aimed for a lineage-specific epidemiological characterization by applying phylodynamic models to genomic data from different countries, representing the most abundant MTBC lineages. Our results suggest that all lineages are associated with similar durations and levels of infectiousness, resulting in similar reproductive numbers. However, L1 and L6 are associated with a delayed onset of infectiousness, leading to longer periods between subsequent transmission events. Together, our findings highlight the role of MTBC genetic diversity in tuberculosis disease progression and transmission.

摘要

结核分枝杆菌复合群（MTBC）谱系在毒力方面表现出显著差异，但这种差异的流行病学后果尚未得到详细研究。在此，我们旨在通过将系统动力学模型应用于来自不同国家的基因组数据，对MTBC谱系进行特定于谱系的流行病学特征分析，这些数据代表了最常见的MTBC谱系。我们的结果表明，所有谱系的传染期和传染水平相似，导致繁殖数相似。然而，L1和L6与传染性的延迟发作有关，导致后续传播事件之间的间隔更长。总之，我们的研究结果突出了MTBC遗传多样性在结核病进展和传播中的作用。