Calcium channels as pharmacological targets for cancer therapy.

Ca, as critical second messengers in biological processes, plays a pivotal role in the regulation of diverse cellular signaling pathways. The dysregulation of calcium signaling is intricately linked to the progression of various cancers. The capacity of Ca to modulate cell death and proliferation, along with its potential for pharmacological manipulation, presents a promising avenue for the development of novel cancer therapeutics. This review provides a comprehensive overview of the classification of Ca channels and their mechanisms of action in oncogenesis, explores the application of Ca blockers in cancer treatment, and underscores the importance of conducting further clinical trials.